MSG study withdrawn: will umami make you eat more?
NCT ID NCT06725615
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study was designed to see if eating foods with MSG (a flavor enhancer) changes how much people eat. Researchers planned to give 75 healthy adults different amounts of MSG in their meals for two weeks and measure their food intake. The study was withdrawn before any participants joined, so no results are available.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Expected to start
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Sep 2025
An estimate. Start dates often move.
- Expected to finish
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Nov 2025
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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20 to 55 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Healthy: as judged by the participant * Age 20-55 years at the time of inclusion, assessed by date of birth; * Proper understanding of the Dutch language, as questionnaires will be in Dutch; * Able to visit Wageningen University, as required for dietary intervention and testing; * Weight 60-80 kg (female) or 65-85 kg (male), as MSG supplementation is based on bodyweight; * Body mass index 20-25 kg/m2; * Having normal taste ability, assessed using Mueller taste strip test, ≥12 out of 20 assessed correctly; * Able to provide informed consent. Exclusion Criteria: * Suffering from endocrine- or gastro-intestinal diseases or other diseases that might influence study outcomes (such as diabetes, Crohn's disease, cardiovascular disease, hypertension, etc.); * Diagnosed with eating disorders (in the past); * Diagnosed with taste or smell disorders in the past six months; * Pregnant or lactating during the study intervention; * Gain or loss of more than 3 kgs in the last three months prior to study entry; * Suffering from lack of appetite for any reason; * Use of medication that may influence the appetite, or medication that may affect body hydration status (medication will be judged by the medical investigator); * Having a food allergy and/or intolerance for foods used in the dietary intervention (e.g. lactose intolerance, gluten intolerance, MSG sensitivity). This will be assessed with an open question; * Consumes more than 14 (women) or 21 (men) glasses of alcohol per week; * Consumes MSG-rich sauces (soy sauce, ketchup and/or curry paste) more than once per day, or consumes more than 3 savoury food items (paprika chips, instant noodles, sundried tomatoes and/or mushrooms) per day. This will be assessed with a frequency of consumption table; * Irregular eating pattern. This will be measured with a frequency of meal/food consumption table, and is defined as: frequency of breakfast consumption less than once per week; * Unwilling to maintain regular exercise pattern during the study period. This will be assessed with a yes/no question; * Unwilling to quit use of soft or hard drugs during the intervention; * Student or personnel of the division of Human Nutrition and Health, Wageningen University; * Participating in any other intervention study/studies or planning to participate in another intervention study during the study period; * Restrained eating score of ≥2.7 (females)/ ≥2.2 (males) measured by Dutch Eating Behaviour Questionnaire.
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Genom att skicka in godkänner du våra Användarvillkor
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Department of Human Nutrition, Wageningen University
Wageningen, Gelderland, 6708WE, Netherlands
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