Can a simple drug prevent dangerous bleeding in C-Sections?
NCT ID NCT07474077
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether giving tranexamic acid before a C-section can reduce the risk of severe postpartum hemorrhage. Researchers will enroll 88 pregnant women with risk factors like previous C-section, twins, or anemia. Half will receive the drug, half a placebo, and blood loss will be measured for 24 hours after delivery.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- tranexamic acid
- What this could lead to
- If it works, this could become a standard preventive treatment to reduce dangerous bleeding after C-sections.
- What could go wrong
- This is a small, single-center trial, so results may not apply broadly. Tranexamic acid can rarely cause blood clots or allergic reactions.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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About 88 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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May 2026
An estimate. Start dates often move.
- Expected to finish
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Mar 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 45 years
- Sex
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Female participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Pregnant woman with risk factors for postpartum haemorrhage undergoing elective and emergency caesarean section in SQUH. * Previous Caesarean Section * Multiple pregnancy, * Polyhydramnios, * Fetal macrosomia (BW \>4kg), * Anemia * Booking BMI\>30 * Previous history of postpartum hemorrhage * Fibroids, * Adenomyosis, * Placenta previa (non- accreta), * Chorioamnionitis. Exclusion Criteria: Woman with conditions like * Placenta accreta spectrum, * Contraindications to tranexamic acid (e.g., hypersensitivity to tranexamic acid), -History of seizure disorders, * Kidney disease, * Thromboembolic disease, * Medical conditions or treatments associated with a high risk of thrombosis
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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