New hope for Hard-to-Treat cancers: experimental drug PT886 enters human trials
NCT ID NCT05482893
First seen Nov 05, 2025 · Last updated May 20, 2026 · Updated 24 times
Summary
This study tests a new drug called PT886 in people with advanced stomach, pancreatic, or bile duct cancers that cannot be removed by surgery or have spread. The trial has two parts: first, finding the safest dose of PT886 alone, then testing it combined with chemotherapy or immunotherapy. About 258 adults will take part to see if the drug is safe and works against these cancers.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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City of Hope (City of Hope National Medical Center, City of Hope Medical Center)
RECRUITINGDuarte, California, 91010, United States
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Dana-Farber Cancer Institute (DFCI)
ACTIVE_NOT_RECRUITINGBoston, Massachusetts, 02215, United States
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Duke Cancer Center
RECRUITINGDurham, North Carolina, 27710, United States
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MD Anderson Cancer Center, GI Medical Oncology Dept
RECRUITINGHouston, Texas, 77030, United States
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NEXT Oncology
RECRUITINGFairfax, Virginia, 22031, United States
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Norton Cancer Institute
RECRUITINGLouisville, Kentucky, 40202, United States
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Sarah Cannon Research Institute (SCRI)
RECRUITINGDenver, Colorado, 80218, United States
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USC Norris Comprehensive Cancer Center
RECRUITINGLos Angeles, California, 90033, United States
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University of Iowa
RECRUITINGIowa City, Iowa, 52242, United States
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University of Pittsburgh Medical Center (UPMC)
RECRUITINGPittsburgh, Pennsylvania, 15232, United States
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University of Wisconsin Carbone Cancer Center - University Hospital
RECRUITINGMadison, Wisconsin, 53792, United States
Conditions
Explore the condition pages connected to this study.