New drug cocktail aims to stop triple negative breast cancer from returning
NCT ID NCT07679360
First seen Jul 01, 2026 · Last updated Sep 10, 2026 · Updated 3 times
Summary
This Phase 3 trial tests whether a combination of two drugs, trastuzumab rezetecan and adebrelimab, can prevent breast cancer from returning in people with triple negative breast cancer who still have cancer cells after initial chemotherapy and surgery. The study compares this new combination to standard treatments chosen by the doctor. About 1000 participants will be randomly assigned to receive either the experimental combination or a standard therapy, and researchers will track how long they live without the cancer coming back.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Trastuzumab Rezetecan and Adebrelimab
- What this could lead to
- If successful, this combination could offer a more effective treatment option for triple negative breast cancer patients who still have cancer after initial therapy, potentially reducing the risk of recurrence.
- What could go wrong
- This is an early-stage Phase 3 trial, and the combination may not prove more effective than existing treatments. Side effects from the drugs could be significant.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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About 1,000 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Sep 2026
- Expected to finish
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Dec 2032
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 75 years
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Pathologically confirmed invasive triple negative breast cancer. 2. Pathologic evidence of residual invasive carcinoma in the breast or axillary lymph nodes following completion of preoperative therapy. 3. Previous neoadjuvant therapy must meet the requirements of the protocol. 4. Has received radical surgery for breast cancer. 5. ECOG PS 0\~1. 6. Adequate organ functions. 7. Women of childbearing potential must be willing to use highly effective form of contraception. Exclusion Criteria: 1. Stage IV metastatic breast cancer. 2. Previous invasive breast cancer or ductal carcinoma in situ. 3. Bilateral breast cancer. 4. Any clinical evidence indicating the exist of recurrent diseases after surgery. 5. History of other malignancy within the last 5 years, excluding cured skin basal cell carcinoma and cervical carcinoma in situ. 6. Previously received antibody coupled drug (ADC) therapy with topoisomerase inhibitors as effective payloads. 7. Previously received HER2 targeted therapy. 8. Active or previously recorded autoimmune or inflammatory diseases. 9. History of immunodeficiency. 10. Participants with known or suspected interstitial pneumonia. 11. Presence of active Hepatitis B. 12. Known to have active tuberculosis infection. 13. Uncontrolled infections requiring intravenous injection of antibiotics, antiviral drugs, or antifungal drugs for treatment. 14. Within the 6 months prior to randomization, there was a history of myocardial infarction, severe/unstable angina, symptomatic congestive heart failure, ≥ Grade 2 supraventricular or ventricular arrhythmias, and any grade of ventricular fibrillation. 15. Known allergy to any investigational drug or its excipients. 16. Other medical conditions that would interfere with study participation or follow-up.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Cancer Hospital of Chinese Academy of Medical Sciences
RECRUITINGBeijing, Beijing Municipality, 100021, China
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