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Ear stimulation may tame POTS symptoms

NCT ID NCT02281097

Symptom relief Sponsor: Vanderbilt University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a mild electrical current applied to the skin of the ear can help people with Postural Orthostatic Tachycardia Syndrome (POTS). POTS causes a rapid heart rate and symptoms like light-headedness and fatigue when standing. The treatment aims to stimulate the vagus nerve through the ear to improve heart rate and reduce symptoms. The trial involves 18 participants and compares the real stimulation to a sham (placebo) version.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
electrical stimulation of the vagus nerve through the skin of the ear
What this could lead to
If it works, this could offer a non-drug way to manage POTS symptoms like light-headedness and fatigue.
What could go wrong
This is a very small early study with only 18 people, so results may not apply to everyone. The sham (placebo) group also gets some stimulation, which could blur the real effect.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

18 people

The number who actually took part.

Started

Jun 2013

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Non-smoking patients who qualify with the criteria of idiopathic postural tachycardia syndrome will be studied. The criteria are: 1. an increase of heart rate of 30 beats/minute or an upright heart rate of \>= 120 bpm, and 2. chronic problems of symptoms during upright posture for at least 6 month. * Subjects must also be able to safely withdrawn from medications that influence heart rate, blood pressure, and hormone levels that regulate blood pressure. * The age limit is 18-75 years. Exclusion Criteria: * Patients that have other major medical problems, such as cancer or heart disease are excluded because the influence of that diagnosis on the symptoms is not known. * Pregnancy.

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Conditions

The condition(s) this trial relates to.

postural orthostatic tachycardia syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postural orthostatic tachycardia syndrome

Contacts and locations

Locations

  • Autonomic Dysfunction Center, Vanderbilt University Medical Center

    Nashville, Tennessee, 37232-2195, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.