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Can a Blood-Clotting gel stop bleeding after tooth extraction for people on blood thinners?

NCT ID NCT07830875

NEW Symptom relief Sponsor: Cumhuriyet University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 21, 2026 · Last updated Sep 21, 2026

Summary

Researchers test whether a local application of tranexamic acid-modified leukocyte- and platelet-rich fibrin (L-PRF) controls bleeding and improves healing after tooth extraction in people taking direct oral anticoagulants. Each participant has two teeth removed, with one socket receiving the modified L-PRF and the other a standard absorbable gelatin sponge. The study measures bleeding 30 minutes after extraction, pain at 24, 48, and 72 hours, and wound healing at 7, 14, and 21 days.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
tranexamic acid-modified leukocyte- and platelet-rich fibrin (L-PRF)
What this could lead to
If it works, this could offer a simple, local way to control bleeding and support healing after tooth extraction for people who take blood thinners, without stopping their medication.
What could go wrong
This is a small, single-center study of 21 people, so the results may not apply broadly. The treatment could fail to outperform the standard gelatin sponge, and local reactions or delayed healing remain possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

21 people

The number who actually took part.

Started

Aug 2025

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥18 years * Receiving treatment with one of the specified direct oral anticoagulants (DOACs) for at least 2 months * No known hypersensitivity to the study materials * No diagnosis of malignant or premalignant lesions * Indication for extraction of at least two non-adjacent teeth Exclusion Criteria: * Refusal to participate or inability/unwillingness to provide written informed consent * History of hypersensitivity or allergy to local anesthetics * Immunosuppression * Acute infection in any tooth planned for extraction * Treatment with antiresorptive medications * Essential or congenital coagulation disorders * Severe cirrhosis * Chronic kidney disease * Uncompensated diabetes mellitus * Uncontrolled hypertension * Pregnancy or breastfeeding

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Patients receiving direct oral anticoagulants

Contacts and locations

Locations

  • Sivas Cumhuriyet University Faculty of Dentistry

    Sivas, Sivas, 58000, Turkey (Türkiye)