Tartar showdown: new toothpaste takes on regular fluoride
NCT ID NCT07223060
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether a toothpaste with stannous fluoride is better at preventing tartar (hardened plaque) on teeth than a regular fluoride toothpaste. One hundred adults in Thailand brushed twice daily for 12 weeks. Researchers measured tartar buildup to see which toothpaste worked better.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- stannous fluoride toothpaste
- What this could lead to
- If it works, this could show that stannous fluoride toothpaste is better at preventing tartar buildup than regular fluoride toothpaste.
- What could go wrong
- This is a small, completed trial with only 100 participants, so results may not apply to everyone. The difference between toothpastes may be small or not meaningful in daily life.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 2/3
Runs two stages together: whether the treatment works, then large-scale confirmation.
- Participants
-
100 people
The number who actually took part.
- Started
-
May 2017
- Finished
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Oct 2017
- Lead sponsor
-
A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Subjects were required to sign an Informed Consent form * Subjects had to be in general good health * Male and female adults between the ages of 18-70 (inclusive) * Six (6) scoreable mandibular anterior teeth free of large restorations or dental prosthetic crowns * Subjects were required to possess a Volpe-Manhold Calculus Index of at least 7.0 * Subjects had to be able to participate for the full duration (20 weeks) of the study Exclusion Criteria: * Presence of orthodontic appliances or removable prosthesis at the lower jaw or more than one mandibular anterior tooth with a prosthetic crown or veneer * Tumor(s) or significant pathology of the soft or hard tissues of the oral cavity * Moderate or advanced periodontal disease * Five or more carious lesions requiring immediate care * Use of antibiotics or steroids any time during one month prior to entry into the study * Participation in any other clinical study or panel test * Pregnant or breast feeding women * History of allergies to dentifrice and personal care ingredients * Allergies to dentifrice products * Medical reasons that prohibit eating or drinking for 4 hours prior to clinical facility visit.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
M U International Oral Science Research, Ltd.
Bangkok, Bangkok, 10250, Thailand