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Shocking the brain back to speech: new hope for stroke survivors

NCT ID NCT03651700

Symptom relief Sponsor: H. Branch Coslett Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether combining transcranial magnetic stimulation (TMS) with language therapy helps people with chronic aphasia—a language disorder after stroke—speak better. 86 participants received either real TMS or a sham version, plus language therapy, over two weeks. The main goal was to see if language scores improved six months later.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Transcranial magnetic stimulation (TMS) and constraint-induced language therapy (CILT)
What this could lead to
If it works, this could point toward a non-invasive treatment to improve language recovery in people with long-term aphasia after stroke.
What could go wrong
This is a phase 2 trial with only 86 participants, so results may not apply to everyone. The treatment is short-term and effects may fade over time.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

86 people

The number who actually took part.

Started

Mar 2019

Finished

Aug 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Clinical evidence and MRI or CT verification of a single left hemisphere stroke with moderate to severe aphasia. * Suffered their stroke at least 6 months prior to their testing * Must be able to understand the nature of the study, and give informed consent Exclusion Criteria: * Multiple strokes (excluding small lacunar strokes) as defined by brain imaging * History of substance abuse * Previous head trauma with loss of consciousness for more than 5 minutes * Psychiatric illness (We note that subjects will be assessed with the 15-item Geriatric Depression scale. Because depression is very difficult to evaluate in aphasic subjects, potential subjects will not be excluded on the basis of the depression score) * Chronic exposure to medications that might be expected to have lasting consequences for the central nervous system (e.g. haloperidol, dopaminergics) * History of or neuropsychological findings suggestive of dementia

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Conditions

The condition(s) this trial relates to.

aphasia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aphasia

Contacts and locations

Locations

  • University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.