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Can medical glue replace stitches after wisdom tooth removal?

NCT ID NCT07735598

Symptom relief Sponsor: University of Turin, Italy Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 30, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This trial compares two ways to close the gum after removing impacted lower wisdom teeth: a medical tissue adhesive (glue) versus traditional silk stitches. Researchers will measure pain, bleeding, healing, and the body's inflammatory response in 47 healthy adults. Each participant will receive both methods on opposite sides of the mouth to see which works better.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
n-hexyl-cyanoacrylate tissue adhesive (Ifabond® Glue) compared to silk sutures for wound closure
What this could lead to
If the glue works as well as stitches, it could offer a faster, less painful option for closing surgical wounds in the mouth.
What could go wrong
This is a small, early-stage trial with only 47 participants, so results may not apply to everyone. The glue might not hold as well as stitches, leading to bleeding or poor healing.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

47 people

The number who actually took part.

Started

Jan 2026

Finished

Jul 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 years or older. * Healthy individuals (ASA I or II) with no history of uncontrolled systemic disease. * Presence of bilateral partially or completely impacted mandibular third molars requiring surgical extraction. * Comparable clinical and radiographic characteristics of both mandibular third molars. * Ability and willingness to provide written informed consent. * Willingness and ability to comply with the study protocol and attend all scheduled follow-up visits. Exclusion Criteria: * Age younger than 18 years. * Absence of bilateral impacted mandibular third molars requiring surgical extraction. * Pregnancy or breastfeeding. * Current smoking. * Uncontrolled systemic diseases or medical conditions affecting wound healing or bone metabolism. * Oncological or hematological disorders. * Inability or unwillingness to provide informed consent or comply with the study protocol and follow-up schedule.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Mandibular third molar/surgery

Contacts and locations

Locations

  • CIR Dental School

    Torino, 10133, Italy