Could your own immune cells fight lung cancer? new trial tests safety

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age 18-75 years, male or female; 2. Imaging findings showing multiple pulmonary nodules persisting after one year of follow-up, clinically diagnosed as multiple lung cancers by two associate senior or higher-level radiologists, two associate senior or higher-level thoracic surgeons, and one associate senior or higher-level oncologist, with patients refusing continued observation; 3. Patients with a history of surgical resection and pathological diagnosis of NSCLC, who subsequently show disease progression on imaging (progression of primary lesion or new nodules) during follow-up or after targeted therapy, diagnosed as lung cancer by a multidisciplinary expert team, and who refuse surgery or other treatments; 4. Ability to obtain a tumor sample of approximately 1-1.5 cm³ via surgery, biopsy, or bronchoscopy for preparation of autologous tumor-infiltrating lymphocytes; 5. ECOG performance status score of 0-2; 6. HGB ≥70 g/L, transfusion-eligible; 7. No severe hepatic, renal, cardiac, or pulmonary dysfunction, meeting the following criteria: Creatinine ≤ 1.5 × ULN; Oxygen saturation \> 90%; Total bilirubin ≤ 1.5 × ULN; ALT and AST ≤ 2.5 × ULN; 8. Estimated survival \> 5 years with complete clinical documentation. Exclusion Criteria: 1. Patients with pathological diagnosis of small cell lung cancer components; 2. Suspicious lesions appearing and follow-up duration less than six months, or remission after anti-inflammatory treatment; 3. Previous history of allogeneic organ transplantation or cytoreductive therapy including lymph node clearance; 4. Patients currently undergoing steroid therapy; 5. Concurrent severe or persistent infections unresponsive to effective control; 6. Concurrent severe autoimmune disease or congenital immunodeficiency; 7. History of severe allergic reactions to biological products (including antibiotics); 8. Active hepatitis (quantitative hepatitis B virus DNA \[HBV-DNA\] above the lower limit of detection for the assay method, or positive hepatitis C antibodies \[HCV-Ab\] with HCV-RNA above the assay method's lower limit of detection); 9. HIV infection or syphilis infection; 10. Female patients who are pregnant, breastfeeding, or planning pregnancy within 12 months; 11. Conditions deemed by the investigator to potentially increase subject risk or interfere with trial results.