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Teens with tics needed for landmark study on hidden symptoms

NCT ID NCT06576726

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

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Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study aims to learn more about sensory and movement difficulties in adolescents with tic disorders, like Tourette syndrome. Researchers will compare teens with and without tics using questionnaires, brain wave tests, and motor tasks. The goal is to identify factors that affect quality of life and guide better treatments in the future.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 351 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2024

Expected to finish

May 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants must be willing to attend Visits 2 and 4 in-person

Ages

11 to 17 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

* Inclusion criteria for adolescents with tic disorder: * adolescent age 11-17 years of age * adolescent diagnosis of chronic tic disorder (Tourette syndrome, chronic motor tic disorder, chronic vocal tic disorder) * English-speaking adolescent and caregiver/adult proxy (as validated questionnaires are in English) * adolescent and caregiver/adult proxy willingness and ability to complete relevant questionnaires * Exclusion criteria for for adolescents with tic disorder: * cognitive or attentional impairment precluding ability of adolescent or caregiver/adult proxy to complete questionnaires and other study measures * adolescent diagnosis of autism spectrum disorder (ASD) or psychotic disorder * adolescent diagnosis of pervasive genetic disorder besides chronic tic disorders and their known comorbidities * adolescent with severe medical conditions unrelated to chronic tic disorders (e.g. uncontrolled seizures, prominent heart conditions) * other variables that might influence ratings outside of the typical presentation of chronic tic disorders * Additional exclusion criteria for EEG tasks for chronic tic disorder sample\*\* * adolescent treatment with stimulant medications or anti-seizure medications within the past 30 days * use of marijuana or recreational substances within the past 30 days * history of seizure * history of hearing loss or abnormalities * history of neuropathy or overt sensory deficit * history of brain surgery or skull-penetrating/deforming trauma * history of stroke, brain cancer, or other significant neurologic illness/disorder \*\* Individuals excluded based on these criteria are ineligible for the EEG portion of the study but can complete the remainder of the study measures. * Inclusion criteria for control (neurotypical adolescent) participants * adolescent age 11-17 years of age * English-speaking adolescent and caregiver/adult proxy (as validated questionnaires are in English) * adolescent and caregiver/adult proxy willingness and ability to complete relevant questionnaires * Exclusion criteria for control sample * history of tics, ADHD, OCD, or other significant neurodevelopmental or neuropsychiatric disorder. \*\* Note: adolescents with history of mood or anxiety disorder are eligible. * cognitive or attentional impairment precluding ability of adolescent or caregiver/adult proxy to complete questionnaires and other study measures * adolescent diagnosis of autism spectrum disorder (ASD) or psychotic disorder * adolescent diagnosis of pervasive genetic disorder * adolescent with severe medical conditions (e.g. uncontrolled seizures, prominent heart conditions) * other variables that might influence ratings * Additional exclusion criteria for EEG tasks for control sample\* * adolescent treatment with stimulant medications or anti-seizure medications within the past 30 days * use of marijuana or recreational substances within the past 30 days * history of seizure * history of hearing loss or abnormalities * history of neuropathy or overt sensory deficit * history of brain surgery or skull-penetrating/deforming trauma * history of stroke, brain cancer, or other significant neurologic illness/disorder

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Vanderbilt University Medical Center

    RECRUITING

    Nashvile, Tennessee, 37232, United States

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