Teens with tics needed for landmark study on hidden symptoms
NCT ID NCT06576726
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study aims to learn more about sensory and movement difficulties in adolescents with tic disorders, like Tourette syndrome. Researchers will compare teens with and without tics using questionnaires, brain wave tests, and motor tasks. The goal is to identify factors that affect quality of life and guide better treatments in the future.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 351 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Oct 2024
- Expected to finish
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May 2030
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Participants must be willing to attend Visits 2 and 4 in-person
- Ages
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11 to 17 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
* Inclusion criteria for adolescents with tic disorder: * adolescent age 11-17 years of age * adolescent diagnosis of chronic tic disorder (Tourette syndrome, chronic motor tic disorder, chronic vocal tic disorder) * English-speaking adolescent and caregiver/adult proxy (as validated questionnaires are in English) * adolescent and caregiver/adult proxy willingness and ability to complete relevant questionnaires * Exclusion criteria for for adolescents with tic disorder: * cognitive or attentional impairment precluding ability of adolescent or caregiver/adult proxy to complete questionnaires and other study measures * adolescent diagnosis of autism spectrum disorder (ASD) or psychotic disorder * adolescent diagnosis of pervasive genetic disorder besides chronic tic disorders and their known comorbidities * adolescent with severe medical conditions unrelated to chronic tic disorders (e.g. uncontrolled seizures, prominent heart conditions) * other variables that might influence ratings outside of the typical presentation of chronic tic disorders * Additional exclusion criteria for EEG tasks for chronic tic disorder sample\*\* * adolescent treatment with stimulant medications or anti-seizure medications within the past 30 days * use of marijuana or recreational substances within the past 30 days * history of seizure * history of hearing loss or abnormalities * history of neuropathy or overt sensory deficit * history of brain surgery or skull-penetrating/deforming trauma * history of stroke, brain cancer, or other significant neurologic illness/disorder \*\* Individuals excluded based on these criteria are ineligible for the EEG portion of the study but can complete the remainder of the study measures. * Inclusion criteria for control (neurotypical adolescent) participants * adolescent age 11-17 years of age * English-speaking adolescent and caregiver/adult proxy (as validated questionnaires are in English) * adolescent and caregiver/adult proxy willingness and ability to complete relevant questionnaires * Exclusion criteria for control sample * history of tics, ADHD, OCD, or other significant neurodevelopmental or neuropsychiatric disorder. \*\* Note: adolescents with history of mood or anxiety disorder are eligible. * cognitive or attentional impairment precluding ability of adolescent or caregiver/adult proxy to complete questionnaires and other study measures * adolescent diagnosis of autism spectrum disorder (ASD) or psychotic disorder * adolescent diagnosis of pervasive genetic disorder * adolescent with severe medical conditions (e.g. uncontrolled seizures, prominent heart conditions) * other variables that might influence ratings * Additional exclusion criteria for EEG tasks for control sample\* * adolescent treatment with stimulant medications or anti-seizure medications within the past 30 days * use of marijuana or recreational substances within the past 30 days * history of seizure * history of hearing loss or abnormalities * history of neuropathy or overt sensory deficit * history of brain surgery or skull-penetrating/deforming trauma * history of stroke, brain cancer, or other significant neurologic illness/disorder
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Vanderbilt University Medical Center
RECRUITINGNashvile, Tennessee, 37232, United States
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Other studies related to the condition(s) this trial covers.
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- Brain scans may reveal why behavioral therapy helps some teens with tics
- Can a dopamine-blocking drug safely control tourette syndrome over years?
- Mapping tic patterns could lead to personalized therapy for tourette syndrome
- Sound waves aimed at the brain could quiet tics without surgery