Leukemia meds may mess with your thyroid – new study to find out how
NCT ID NCT07200882
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study will check how certain leukemia drugs (called tyrosine kinase inhibitors) affect the thyroid gland in people with chronic myeloid leukemia. Researchers will measure thyroid hormone levels in 76 newly diagnosed adults over time. The goal is to learn how often thyroid problems occur, not to test a new treatment.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 76 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Nov 2025
An estimate. Start dates often move.
- Expected to finish
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Dec 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Philadelphia chromosome positive. CML patients
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients age from 18 to 65 year Newly diagnosed CML patients with Philadelphia chromosome positive based on peripheral blood findings and molecular analysis for the BCR-ABL mutation initiating ttt with a TKI (Philadelphia chromosome positive. CML patients ) Exclusion Criteria: * -any history of using drugs interfering with TKI or having effect on thyroid function (Dexamethasone, Phenytoin, Carbamazepine, Rifampin and Phenobarbital) Patients with a history of thyroid disease ( hypo or hyperthyroidism or auto immunity )or are already on treatment for thyroid dysfunction * pregnancy and lactation * concomitant use of oral contraceptive pills or corticosteroids. * Other malignancies requiring concurrent treatment * previous ttt with TKI
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
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Other studies related to the condition(s) this trial covers.
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