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Brain zaps show promise for tough schizophrenia symptoms

NCT ID NCT05100888

Symptom relief Sponsor: Semmelweis University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a type of brain stimulation called theta-burst TMS to see if it can safely improve negative symptoms (like lack of motivation) and thinking problems in people with schizophrenia. 76 adults with stable schizophrenia took part in a double-blind trial where some received real stimulation and others a sham. The goal was to measure changes in symptoms, memory, and brain activity.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

76 people

The number who actually took part.

Started

Jul 2022

Finished

Mar 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. diagnosis of schizophrenia or schizoaffective disorder; 2. clinically stabilized on antipsychotic: a stable dose of antipsychotic medication for \>4 weeks; 3. age 18-60 years, and 4. presence of negative symptoms (based on PANSS): a negative subscore ≥16 points and \[one of items N1-N7 scoring ≥4 or two items N1-N7 scoring ≥3\] Exclusion Criteria: 1. any significant neurological illness; 2. mental retardation 3. history of head injury with loss of consciousness for more than 1 hour 4. history of epileptic seizures or epileptic activity on the baseline EEG (evaluated by an expert in clinical EEG and epilepsy), 5. alcohol or drug abuse within the past 3 months, and 6. depressive episode or antidepressant treatment in the past 4 weeks. 7. Severe positive symptoms inferfere with cognitive tests 8. Implanted pacemaker, implanted drug pump, cochlear implant, implanted defibrillator, implanted neurostimulator or any other TMS incompatible implanted metal device 9. Skin surface is severly injured in the stimulated region of the skull 10. Sclerosis multiplex 11. Pregnancy 12. Severe sleep deprivation 13. Severe heart failure 14. Increased intracranial pressure 15. Untreated migrain

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Conditions

The condition(s) this trial relates to.

schizoaffective disorder schizophrenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Schizophrenia Transcranial magnetic stimulation repetitive

Contacts and locations

Locations

  • Department of Psychiatry and Psychotherapy

    Budapest, Budapest, 1083, Hungary

More trials for these conditions

Other studies related to the condition(s) this trial covers.