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New head zaps aim to ease Parkinson's tremors without surgery

NCT ID NCT07312279

Symptom relief Sponsor: Zhongnan Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a non-invasive device called Temporal Interference Stimulation (TIS) to see if it can improve movement in people with Parkinson's disease. The device uses electrical fields to stimulate deep brain areas without surgery. Twenty-four adults with mild to moderate Parkinson's will receive a single session, and researchers will check their symptoms right after and one month later.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Temporal Interference Stimulation (TIS) device
What this could lead to
If it works, this could point toward a non-invasive way to ease movement symptoms in Parkinson's disease, potentially guiding better treatments.
What could go wrong
This is a very early, small study (24 people) testing only a single session. It may not produce lasting benefits, and the stimulation is less precise than standard deep brain stimulation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 24 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Dec 2025

An estimate. Start dates often move.

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Adult males or females aged 40 years or above; 2. Diagnosed with idiopathic Parkinson's disease according to the UK Brain Bank Criteria, with onset after 40 years of age; 3. Previous or current dopaminergic replacement therapy (e.g., levodopa) with good response; (4) Hoehn and Yahr (H\&Y) stage 1.5-2.5; 4. Ability to walk independently without assistive devices for at least 5 minutes; 5. Absence of severe freezing of gait (FOG); 6. Disease duration ≥2 years since diagnosis, with stable clinical condition and ability to comply with study assessments and interventions; 7. Stable medication dosage for at least 4 weeks prior to the study; 8. Hoehn and Yahr (H\&Y) stage 1.5-2.5; 9. Signed informed consent, with the participant or legal guardian capable of understanding and willing to participate in the study. Exclusion Criteria: 1. Presence of other neurological disorders that may interfere with the study 2. Mild or greater cognitive impairment (MoCA score ≤23) 3. Orthopedic or other health conditions that may affect gait or balance 4. Contraindications to MRI scanning, such as claustrophobia 5. History of antipsychotic, antidepressant, or other medications that may affect dopamine levels 6. Other significant psychiatric history 7. Contraindications including history of epilepsy, traumatic brain injury, or implanted metal devices in the brain or heart (e.g., stimulators, pacemakers) 8. History of electroconvulsive therapy 9. Concurrent participation in other gait- or balance-related intervention training 10. Physician-diagnosed cardiovascular risk factors for exercise.

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Conditions

The condition(s) this trial relates to.

Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Parkinson's disease Temporal interference stimulation (TIS)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

More trials for these conditions

Other studies related to the condition(s) this trial covers.