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Zapping the brain to lift Post-Stroke depression?

NCT ID NCT06598670

Symptom relief Sponsor: Riphah International University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a gentle, non-invasive brain stimulation technique called tDCS could reduce depression and improve thinking in people who had a stroke. Sixty participants received either tDCS or breathing exercises over eight weeks. The goal was to see if tDCS could be a helpful add-on treatment for post-stroke depression.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
transcranial direct current stimulation (tDCS)
What this could lead to
If it works, this could offer a non-drug option to help with depression and thinking problems after a stroke.
What could go wrong
This is a small, completed study that only looked at short-term effects. The results may not apply to everyone, and tDCS might not work for all types of post-stroke depression.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

60 people

The number who actually took part.

Started

Oct 2024

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

25 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Stroke for more than 6 months * Both gender with equal ratio on stroke severity basis * Depression diagnosed by Psychiatrist * Mild and moderate Depression at PHQ-9 * National Institutes of Health Stroke Scale (NIHSS) for severity level; Mild (1-4), Moderate (5-15), Moderate to Severe (16-20), Severe (21-42) Exclusion Criteria: * Any medical condition like cardiac arrhythmias, uncontrolled hypertension. * Individual with any pacemaker and metal implant in body. * Patient with any other neurological and psychiatric condition.

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Conditions

The condition(s) this trial relates to.

Depression stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Post stroke depression

Contacts and locations

Locations

  • Pakistan Railway General Hospital

    Rawalpindi, Punjab Province, 466000, Pakistan

More trials for these conditions

Other studies related to the condition(s) this trial covers.