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Supercharged immune cells take on HPV cancers

NCT ID NCT02858310

First seen Nov 01, 2025 · Last updated Jun 17, 2026 · Updated 33 times

Summary

This study tested a new treatment for cancers caused by HPV-16, such as cervical, throat, and anal cancers. Researchers took patients' white blood cells, added genes to help them recognize and attack cancer cells with the HPV E7 protein, and infused them back. The trial included 224 adults who had already tried standard treatments. The goal was to find a safe dose and see if the therapy could shrink tumors.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • National Institutes of Health Clinical Center

    Bethesda, Maryland, 20892, United States

  • Rutgers Cancer Institute of New Jersey

    New Brunswick, New Jersey, 08901, United States

Conditions

The condition(s) this trial relates to.

cervical intraepithelial neoplasia dysplasia of cervix human papilloma virus infection human papillomavirus-related squamous cell carcinoma in situ carcinoma vulva cancer vulvar disease vulvar neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.