New drug cocktail targets rare childhood cancers
NCT ID NCT05407441
First seen Nov 01, 2025 · Last updated May 23, 2026 · Updated 28 times
Summary
This study tests a combination of three drugs (tazemetostat, nivolumab, and ipilimumab) for children with rare tumors that lack certain proteins (INI1 or SMARCA4). The goal is to find a safe dose and see if the drugs can shrink tumors. About 49 children with specific cancers like atypical teratoid rhabdoid tumor or epithelioid sarcoma will participate.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Boston Children's Hospital
Boston, Massachusetts, 02115, United States
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Texas Children's Hospital
Houston, Texas, 77030, United States
Conditions
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