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Numbing injection may cut appendicitis pain before emergency surgery

NCT ID NCT06808737

Symptom relief Sponsor: Ankara City Hospital Bilkent Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a numbing injection into the abdominal wall muscles (called a TAP block) can reduce pain for people with acute appendicitis waiting for emergency surgery. 105 adults in the emergency department received the block, and researchers measured how much pain medication they needed over 24 hours. The goal is to find a better way to control pain before surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Transversus Abdominis Plane (TAP) block (a numbing injection into the abdominal wall muscles)
What this could lead to
If it works, this could offer a simple way to ease severe pain from appendicitis before surgery, reducing the need for strong painkillers.
What could go wrong
This is a small, completed study with 105 people, so results may not apply to everyone. The TAP block may not work well for all patients or could have side effects like infection or bleeding.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

105 people

The number who actually took part.

Started

May 2024

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients diagnosed with acute appendicitis in the emergency department and scheduled for definitive surgery following general surgical consultation: patients will have their Alvarado score calculated based on history, physical examination, and laboratory tests, and acute appendicitis will be confirmed by ultrasound and/or contrast-enhanced/non-contrast-enhanced abdominal CT. * Patients aged 18 and over * Patients who provide written consent Exclusion Criteria: * Patients with abdominal wall anatomical abnormalities * Patients with known local anesthetic allergies * Body mass index \> 30 * Patients weighing less than 45 kg * Coagulopathy * Patients with opioid, alcohol, or substance addiction * Patients with skin infections at the site of local anesthetic application * Pregnant or breastfeeding patients * Hemodynamically unstable patients * Patients with liver or kidney failure * Patients with chronic pain disorders * Patients who have difficulty cooperating or have language barriers * Patients who do not provide written consent * Patients under 18 years of age

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Conditions

The condition(s) this trial relates to.

agnosia appendicitis Emergencies

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute appendicitis

Contacts and locations

Locations

  • Ankara City Hospital

    Ankara, Yenimahalle, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.