New drug cocktail aims to fight incurable liver cancer
NCT ID NCT05320692
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 3 trial tests whether adding two drugs (camrelizumab and rivoceranib) to a standard liver cancer procedure (TACE) helps people with incurable liver cancer live longer without their disease getting worse. About 423 participants are randomly assigned to get either the combination or TACE alone. The study is active but no longer recruiting.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- camrelizumab and rivoceranib (apatinib)
- What this could lead to
- If successful, this combination could offer a new treatment option to slow liver cancer progression and extend survival for people with incurable disease.
- What could go wrong
- This is an early-phase 3 trial, so results are not yet confirmed. The combination may cause more side effects than TACE alone, and it may not improve outcomes for all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
-
423 people
The number who actually took part.
- Started
-
Aug 2022
- Expected to finish
-
Jul 2026
An estimate. End dates often move.
- Lead sponsor
-
A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
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Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Voluntarily participate in this study and sign informed consent. 2. Subjects diagnosed with HCC or clinically diagnosed with HCC by histopathology / cytology. 3. Baseline imaging examination has at least one measurable lesion. 4. Child-Pugh liver function rating was Grade A Within 7 days before randomization. 5. ECOG PS score within 7 days before randomization: 0 or 1. Other protocol defined inclusion criteria could apply. Exclusion Criteria: 1. Known hepatocholangiocarcinoma, sarcomatoid hepatocellular carcinoma, mixed cell carcinoma and lamellar cell carcinoma. 2. Subjects who are ready for or have previously received organ or allogeneic bone marrow transplantation. 3. Has any active autoimmune disease or a history of autoimmune disease and may relapse. 4. Suffering from hypertension and can not be well controlled by antihypertensive drugs. 5. With clinical symptoms or diseases of the heart that are not well controlled. 6. Previous or current central nervous system metastasis. 7. The subject has congenital or acquired immune deficiency (such as HIV infection). 8. Thrombotic or embolic events occurred within 6 months prior to the start of study treatment. 9. A history of gastrointestinal hemorrhage or a clear tendency to gastrointestinal bleeding within 6 months prior to the start of study treatment. 10. Abdominal fistula, gastrointestinal perforation or abdominal abscess occurred within 6 months prior to the start of study treatment. 11. Severe, unhealed or cracked wounds and active ulcers or untreated fractures. 12. Known genetic or acquired bleeding or thrombotic tendencies. 13. Severe infection occurred within 4 weeks prior to the start of study treatment. 14. Received live attenuated vaccine treatment within 28 days prior to the start of study treatment. 15. Other investigational drugs were received within 28 days prior to the start of study treatment. 16. According to the assessment of investigator, the subject has other factors that may interfere with the results of the study or cause the forced termination of the study. Other protocol defined exclusion criteria could apply.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Zhongshan Hospital, Fudan University
Shanghai, Shanghai Municipality, 200032, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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