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New drug cocktail aims to fight incurable liver cancer

NCT ID NCT05320692

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tests whether adding two drugs (camrelizumab and rivoceranib) to a standard liver cancer procedure (TACE) helps people with incurable liver cancer live longer without their disease getting worse. About 423 participants are randomly assigned to get either the combination or TACE alone. The study is active but no longer recruiting.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
camrelizumab and rivoceranib (apatinib)
What this could lead to
If successful, this combination could offer a new treatment option to slow liver cancer progression and extend survival for people with incurable disease.
What could go wrong
This is an early-phase 3 trial, so results are not yet confirmed. The combination may cause more side effects than TACE alone, and it may not improve outcomes for all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

423 people

The number who actually took part.

Started

Aug 2022

Expected to finish

Jul 2026

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Voluntarily participate in this study and sign informed consent. 2. Subjects diagnosed with HCC or clinically diagnosed with HCC by histopathology / cytology. 3. Baseline imaging examination has at least one measurable lesion. 4. Child-Pugh liver function rating was Grade A Within 7 days before randomization. 5. ECOG PS score within 7 days before randomization: 0 or 1. Other protocol defined inclusion criteria could apply. Exclusion Criteria: 1. Known hepatocholangiocarcinoma, sarcomatoid hepatocellular carcinoma, mixed cell carcinoma and lamellar cell carcinoma. 2. Subjects who are ready for or have previously received organ or allogeneic bone marrow transplantation. 3. Has any active autoimmune disease or a history of autoimmune disease and may relapse. 4. Suffering from hypertension and can not be well controlled by antihypertensive drugs. 5. With clinical symptoms or diseases of the heart that are not well controlled. 6. Previous or current central nervous system metastasis. 7. The subject has congenital or acquired immune deficiency (such as HIV infection). 8. Thrombotic or embolic events occurred within 6 months prior to the start of study treatment. 9. A history of gastrointestinal hemorrhage or a clear tendency to gastrointestinal bleeding within 6 months prior to the start of study treatment. 10. Abdominal fistula, gastrointestinal perforation or abdominal abscess occurred within 6 months prior to the start of study treatment. 11. Severe, unhealed or cracked wounds and active ulcers or untreated fractures. 12. Known genetic or acquired bleeding or thrombotic tendencies. 13. Severe infection occurred within 4 weeks prior to the start of study treatment. 14. Received live attenuated vaccine treatment within 28 days prior to the start of study treatment. 15. Other investigational drugs were received within 28 days prior to the start of study treatment. 16. According to the assessment of investigator, the subject has other factors that may interfere with the results of the study or cause the forced termination of the study. Other protocol defined exclusion criteria could apply.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Zhongshan Hospital, Fudan University

    Shanghai, Shanghai Municipality, 200032, China

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