Sugar study scans brains to uncover why we crave sweets
NCT ID NCT06015490
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This pilot study tested whether researchers can measure how different sugars (sucrose, glucose, and fructose) affect metabolism, brain activity, and food preferences in healthy adults. Seven participants consumed flavored sugar drinks multiple times and underwent brain scans and metabolic tests. The goal was to see if the methods work, not to draw firm conclusions about sugar's effects.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Sucrose, glucose, and fructose drinks
- What this could lead to
- If successful, this could help researchers understand how different sugars influence cravings and eating behavior.
- What could go wrong
- This is a very small pilot study with only 7 participants, so results may not apply to the general population. It is designed to test feasibility, not to prove any treatment works.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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7 people
The number who actually took part.
- Started
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Sep 2023
- Finished
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Jul 2024
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 45 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. BMI between 18.5-25 kg/m2 2. Not pregnant or planning to become pregnant during study participation 3. Residing in the Roanoke area and/or willing/able to attend sessions at the Fralin Biomedical Research Institute (FBRI) at Virginia Tech Carilion 4. Weigh at least 110 lbs Exclusion Criteria: 1. Current inhaled nicotine use 2. History of alcohol dependence. 3. Current or past diagnosis of cardiometabolic disease or problems, including diabetes, endocrine, heart, or thyroid problems, that may influence study outcomes 4. Hemoglobin A1C \>5.7% 5. Taking medications known to influence study measures (including attention-deficit/hyperactivity disorder (ADHD), allergy, antidepressant, antipsychotic, anxiolytic, birth control, blood pressure, blood glucose, cholesterol, thyroid, sleep, or weight loss medications) 6. Active medical or neurologic disorder, including cardiometabolic conditions or gastrointestinal conditions that may influence study outcomes 7. Recent change in body weight (gain or loss of \> 5 lbs within the past 3 months) 8. Current shift work (typical pattern of work/activity overnight) 9. Previous weight loss surgery 10. Adherence to a special diet within the past 3 months (e.g., low-carb or ketogenic diet, exclusion of food groups/specific macronutrients, intermittent fasting, etc.) 11. Allergy to any food or ingredient included in the study diets, meals, or beverages 12. Currently pregnant or planning to become pregnant during study participation 13. Claustrophobia 14. Contraindications for MRI, including pacemaker, aneurysm clips, neurostimulators, cochlear or other implants, metal in eyes, regular work with steel, etc. (Note: This is an fMRI-specific exclusion criterion. Participants may be allowed to participate in all other study sessions and measures that do not involve fMRI.) 15. Contraindications for bioelectrical impedance analysis, specifically implanted devices 16. Use of substances (or combinations of substances) in doses and frequencies that could influence neural outcomes of study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Fralin Biomedical Research Institute at Virginia Tech Carilion
Roanoke, Virginia, 24016, United States
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