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Blood test lets docs cut steroids for kids with GVHD

NCT ID NCT05090384

First seen May 10, 2026 · Last updated May 18, 2026 · Updated 3 times

Summary

This study tested whether a blood test (GVHD biomarkers) could help doctors safely reduce steroid doses in children with graft-versus-host disease (GVHD) after a bone marrow transplant. Fifty children with low-risk GVHD were enrolled. The goal was to see if quick steroid tapering based on biomarker results could maintain treatment success while lowering the risk of serious steroid side effects like infections, bone damage, and growth problems.

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Contacts and locations

Locations

  • Boston Children's Hospital Dana Farber Cancer Institute

    Boston, Massachusetts, 02115, United States

  • Children's Healthcare of Atlanta

    Atlanta, Georgia, 30322, United States

  • Children's Hospital of Los Angeles

    Los Angeles, California, 90027, United States

  • Children's Hospital of Philadelphia

    Philadelphia, Pennsylvania, 19104, United States

  • Children's National Hospital

    Washington D.C., District of Columbia, 20010, United States

  • Icahn School of Medicine at Mount Sinai

    New York, New York, 10029, United States

  • Medical College of Wisconsin / Children's Wisconsin

    Milwaukee, Wisconsin, 53226, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Texas Children's Hospital, Baylor College of Medicine

    Houston, Texas, 77030, United States

  • The Hospital for Sick Children

    Toronto, Ontario, M5S, Canada

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37235, United States

Conditions

Explore the condition pages connected to this study.