Could stem cells heal painful fistulas in kids with Crohn's?

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria 1. Males and females aged 13-17 with a diagnosis of Crohn's disease for at least six months duration. 2. Single and Multi-tract Perianal fistula, with or without previous failed surgical repair. 3. Have no contraindications to MR evaluations: e.g. pacemaker or magnetically active metal fragments, claustrophobia 4. Ability to comply with protocol 5. Competent and able to provide written informed consent 6. Concurrent Crohn's-related therapies with stable doses corticosteroids, 5- ASA drugs, immunomodulators, anti-TNF therapy, anti-integrin and anti-interleukin therapies are permitted. 7. Agree to use birth control or abstinence to avoid pregnancy during the study Exclusion Criteria 1. Inability to give informed consent. 2. Clinically significant medical conditions within the six months before administration of MSCs: e.g. myocardial infarction, active angina, congestive heart failure or other conditions that would, in the opinion of the investigators, compromise the safety of the subject. 3. Specific exclusions: 1. Hepatitis B or C 2. HIV 3. Abnormal AST or ALT at screening (defined as \>/+2x ULN) 4. History of colon cancer in the past two years, or treatment for other cancers within the last 6 months. 5. Investigational drug within one month of treatment 6. Pregnant or breast feeding or trying to become pregnant. 7. Presence of a rectovaginal or perineal body fistula 8. Change in Crohn's immunosuppressive regimen within the 2 months prior to enrollment 9. Uncontrolled intestinal Crohn's disease which will require escalation for medical therapy or surgery within 2 months of enrollment 10. Severe anal canal disease that is stenotic and requires dilation 11. Female participant unwilling to agree to use acceptable contraception methods during participation in study