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Desperate knee pain patient gets experimental stem cell treatment

NCT ID NCT04604288

Symptom relief Sponsor: Hope Biosciences Research Foundation Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended) This study
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a stem cell treatment for one person with severe, long-term knee pain from osteoarthritis who had no other options left. The patient received stem cells from their own fat, given both through a vein and directly into the knee joints. The goal was to see if the treatment was safe and could help ease pain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria 1. Documented diagnosis of bilateral knee pain. 2. Hemodynamically stable. Exclusion Criteria 1. Immunosuppression as defined by WBC \< 3, 000 cells/ml at baseline screening. 2. Subjects with pro-coagulant disease processes such as Factor V Leiden deficiency, Factor C and S deficiency, anti-thrombin deficiency, prothrombin mutation, and dysfibrinogenemia. 3. Subjects with abnormal vital signs, abnormal liver or kidney function, and hematological abnormalities specifically: 1. BP systolic: \>160 or \<100 mmHg, DBP: \>100 SBP or \<50mmHg 2. Pulse: \<60 or \>105 bpm 3. Respiratory Rate: \<9 and \>25 breaths per minute 4. Temperature: \>99.9 degrees Fahrenheit 5. O2 saturation: \<92% 6. Liver enzymes \>2x upper limit of normal (ULN) 7. Abnormal bilirubin unless due to benign unconjugated hyperbilirubinemia 8. eGFR \<60 mL/min/ 1.73 m2 by CKD-EPI 9. HbA1C \>9% 10. Hb \<10 mg/dL 11. Platelet Count \<100,000 4. Other acute or chronic medical conditions that, in the opinion of the investigator, may increase the risks associated with study participation or HB-adMSCs administration. 5. Any abnormal, inexplicable laboratory result with no obvious cause defined. 6. Participation in other interventional research studies. 7. Unwillingness to return for follow-up visits.

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Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis susceptibility 6 osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Knee pain chronic Osteo arthritis knee

Contacts and locations

Locations

  • Hope Biosciences Stem Cell Research Foundation

    Sugar Land, Texas, 77478, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.