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Do statins block exercise benefits? new study investigates

NCT ID NCT06841536

Knowledge-focused Sponsor: University of the Faroe Islands Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at how taking statins (a common cholesterol-lowering drug) along with a structured exercise program affects muscle cells and overall fitness in adults aged 40-65 with high cholesterol. 120 participants were split into four groups: exercise plus placebo, exercise plus statin, statin alone, or placebo alone. The goal was to see if statins interfere with the positive effects of exercise on muscle energy centers and aerobic capacity. Results will help understand how to best combine these treatments.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Atorvastatin 80 mg
What this could lead to
If successful, this study could clarify whether statins interfere with exercise benefits, helping doctors tailor cholesterol treatment and exercise advice.
What could go wrong
This is a completed early-stage study with 120 participants. Results may not apply to everyone, and the findings are exploratory—not a direct treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

120 people

The number who actually took part.

Started

May 2025

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age: 40-65 years * LDL-C \> 4.0 mmol/L. Exclusion Criteria: * Diagnosed with serious chronic disease including type 1 or 2 diabetes. * Cancer. * A history of atherosclerotic cardiovascular disease. * A history of major depression or other severe psychiatric disorders. * Severe renal dysfunction (creatinine clearance \<30 mL/min). * Severe hepatic impairment. * Active pregnancy or breast feeding. * Active cigarette or e-cigarette smoker. * Regular (\>2 hours pr week) aerobic high-intensity exercise training.

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Conditions

The condition(s) this trial relates to.

Dyslipidemias hyperlipidemia inherited lipid metabolism disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dyslipidemias

Contacts and locations

Locations

  • University of the Faroe Islands

    Tórshavn, 100, Faroe Islands

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