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Antidepressants and anesthesia: does Long-Term SSRI use shift propofol dosing?

NCT ID NCT07822295

Knowledge-focused Sponsor: Kocaeli City Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 16, 2026 · Last updated Sep 17, 2026 · Updated 1 time

Summary

Researchers are studying whether adults who take SSRI or SNRI antidepressants long term need different amounts of propofol during planned spine surgery compared with adults who do not take these medicines. The study will follow 216 adults, half of whom take an SSRI or SNRI, and all receive routine anesthesia. The team will record propofol and remifentanil doses, blood pressure, heart rate, oxygen levels, anesthesia depth, and recovery time. The study does not change any antidepressant treatment or assign participants to groups.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If a link exists, anesthesiologists could adjust propofol dosing for patients who take SSRI or SNRI antidepressants, which may improve comfort and recovery after spine surgery.
What could go wrong
This observational study can show a pattern but cannot prove that antidepressants cause any difference in propofol needs. Other patient factors, such as age, weight, and pain, may explain the results.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 216 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population will be drawn from patients scheduled for elective spine surgery at Kocaeli City Hospital in Kocaeli, Türkiye. Potential participants will be identified during routine preoperative evaluations in the anesthesia clinic or relevant inpatient surgical wards before surgery.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 1\. Study period: Between October 2026 and April 2027, 2. Study location: Kocaeli City Hospital Operating Rooms, 3. Type of surgery: Patients scheduled for spinal surgery, 4. Medication use: Patients using chronic SSRI or SNRI group antidepressants in the preoperative period, but not using antipsychotics or other group antidepressants (e.g., TCA, MAOI, atypical antidepressants), 5. Age criterion: Adult individuals aged 18 and over, 6. ASA classification: Patients in ASA 2-3 group, Exclusion Criteria: * 1\. Patients who cannot give informed consent and individuals under 18 years of age, 2. Patients with an ASA (American Society of Anesthesiologists) physical status classification of ASA IV or higher, 3. Cases requiring emergency surgical intervention, 4. Patients undergoing surgery due to trauma, 5. Patients using antidepressants other than selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), 6. Cases maintained with inhalation anesthesia.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic ssri/snri use and intraoperative propofol requirements

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Kocaeli City Hospital

    Kocaeli, Izmit, 41000, Turkey (Türkiye)