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Spinal implant shows promise for Parkinson's mobility

NCT ID NCT04956770

Symptom relief Sponsor: Jocelyne Bloch Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a spinal stimulation device to help people with advanced Parkinson's disease walk better and improve balance. Two participants received an implanted stimulator and underwent rehabilitation for 3 to 5 months. The goal was to see if the approach is safe and could improve leg muscle control.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Targeted Epidural Spinal Stimulation (TESS) system
What this could lead to
If it works, this could point toward a new way to help people with advanced Parkinson's walk better and improve balance.
What could go wrong
This was a very small feasibility study with only 2 participants, so results may not apply to others. The procedure involves surgery and implant risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

2 people

The number who actually took part.

Started

Jun 2021

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Idiopathic Parkinson's disease with III-IV Hoehn-Yahr stage, exhibiting severe gait difficulties and postural instability * With Medtronic DBS implant and receiving medication for Parkinson's disease * Aged 18 to 80 years * Stable medical, physical and psychological condition as considered by the Investigators in accordance with treating physician and treating neurologist. * Must agree to comply in good faith with all conditions of the study and to attend all required study training and visit * Must provide and sign the study's Informed Consent prior to any study-related procedures Exclusion Criteria: * Severe or chronic medical disorder pre-existing PD diagnosis affecting rehabilitation * Active oncological disease requiring heavy treatments and frequent MRI controls * Having an implanted device that is active (e.g., pacemaker, implantable cardiac defibrillator) whose interference with the investigational system's neurostimulator (Activa RC) is not confirmed safe by the CE-mark of the device, or having an indication that might lead to implantation of such device * Inability to follow study procedures, e.g. due to language problems, psychological disorders, dementia as considered by the Investigators in accordance with treating physician and treating neurologist * Hematological disorders with an increased risk of hemorrhagic event during surgical interventions * Life expectancy of less than 12 months * Pregnant or breast feeding * Participation in another interventional study

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Conditions

The condition(s) this trial relates to.

Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Parkinson disease

Contacts and locations

Locations

  • CHUV

    Lausanne, Canton of Vaud, 1011, Switzerland

More trials for these conditions

Other studies related to the condition(s) this trial covers.