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Spinal magnetic stimulation plus treadmill training shows promise for Parkinson's gait

NCT ID NCT05938673

Symptom relief Sponsor: University of Sao Paulo General Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a non-invasive magnetic stimulation of the spinal cord, combined with treadmill walking, could improve gait problems in people with Parkinson's disease. 76 participants with moderate Parkinson's and walking difficulties received either real or sham stimulation during treadmill sessions. The goal was to see if the combination could boost walking speed and reduce fall risk more than treadmill training alone.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
repetitive transspinal magnetic stimulation (rTSMS)
What this could lead to
If effective, this combination therapy could offer a new, non-drug way to improve walking and reduce fall risk in Parkinson's patients.
What could go wrong
This is a single, completed trial with 76 participants. Results may not apply to all Parkinson's patients, and benefits might be small or short-lived.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

76 people

The number who actually took part.

Started

Jun 2023

Finished

Jan 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Men and women over the age of 18; * Participants with PD at Hoehn Yahr stages between 2 and 4 (moderate disease) while on-medication (i.e., at the time when their usual dopaminergic medication is clinically effective), whose primary symptom includes gait disturbance (score equal to or greater than 1 in subitem 2.12 of the MSD-UPDRS scale). Patients will be evaluated for the presence of freezing gait (freezing) through the Freezing of Gait Score (FOG-SCORE). * While on on-medication, be able to walk independently for 30 meters or with a unilateral assistive device. * Mini Mental State Examination (MMSE) score greater than or equal to 23. * Sign the informed consent form. Exclusion Criteria: * Patients with unstabilized psychiatric comorbidities; * Individuals who have other neurological disorders, musculoskeletal, orthopedic, cardiovascular and respiratory disorders that may affect the ability to walk on the treadmill will be excluded. * Individuals with labyrinthine problems, using medication that may interfere with balance and performance in tests and treadmill training will be excluded. * Individuals who have undergone deep brain stimulation surgery or epidural spinal cord stimulation will be excluded. * Patients with uncontrolled infection or other uncontrolled pre-existing medical conditions (eg uncontrolled diabetes, high blood pressure, symptomatic lung or heart disease); * Concomitant treatment with other experimental drugs; * Pregnant or breastfeeding women. * Presence of chronic low back and lower limb pain. * Patients who cannot walk without assistance (cane, crutch, walker) or help from another person. * Patients with metal implants and a cardiac pacemaker. * Patient with a history of neurosurgery.

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Conditions

The condition(s) this trial relates to.

Gait Disorders, Neurologic Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gait disorders, neurologic Parkinson disease

Contacts and locations

Locations

  • Hospital das Clínicas da Faculdade de Medicina da USP

    São Paulo, São Paulo, 05403000, Brazil

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