Spine scan showdown: MRI vs PET/CT – safety and clarity compared
NCT ID NCT07640386
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at 120 adults with neck or lower back spine issues to compare two types of scans: contrast-enhanced MRI and FDG-PET/CT. Researchers checked how clear the images were and whether the scans caused any short-term changes in kidney function or blood counts. The goal was to help doctors choose the best imaging method for spinal problems.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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120 people
The number who actually took part.
- Started
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Apr 2025
- Finished
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Jan 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Participants will be recruited from the general population through community outreach, advertisements, and screening visits. Individuals who meet the eligibility criteria will be invited to participate.
- Ages
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Children (under 18), adults (18 to 64) and older adults (65 and over)
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age 18 years or older. * Clinically suspected or confirmed cervical or lumbar spinal pathology. * Presence of symptoms suggestive of spinal disease, including radiculopathy, localized spinal pain, neurological deficits, or suspected metastatic involvement. * Referred for diagnostic evaluation with contrast-enhanced MRI or FDG-PET/CT according to routine clinical indications. * Availability of baseline clinical and laboratory data, including renal function assessment. * Ability to provide informed consent. Exclusion Criteria: * Severe renal impairment (eGFR \<30 mL/min/1.73 m²) or acute kidney injury. * Known hypersensitivity to gadolinium-based contrast agents or 18F-FDG. * Contraindications to MRI, including non-compatible metallic implants or severe claustrophobia. * Pregnancy or breastfeeding. * Uncontrolled diabetes mellitus (blood glucose \>200 mg/dL at the time of PET/CT examination). * Active systemic infection or inflammatory condition requiring immediate treatment. * Inability to complete the required imaging procedures. * Incomplete clinical, laboratory, or imaging data required for study evaluation.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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(MISR University Scientific Research Innovation Committee,
Giza, Giza Governorate, 43556, Egypt