New shot could stop dangerous skin flares before they start

NCT ID NCT04399837

Completed Prevention Sponsor: Boehringer Ingelheim Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 01, 2026 · Updated 28 times

Summary

This study tested a medicine called spesolimab to see if it can prevent flare-ups in people with generalized pustular psoriasis (GPP), a rare and serious skin condition. 123 people aged 12 to 75 with clear or nearly clear skin joined the study. They received either one of three doses of spesolimab or a placebo as a monthly injection for 11 months. The main goal was to see how long it took for a flare to happen, if at all.

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Contacts and locations

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Locations

1stPavlov St.Med.Univ.St.-Petersburg Res.Inst.

Saint Petersburg, 197022, Russia
Arthritis Clinical Research Trials

Cape Town, 7405, South Africa
Bezmi Alem Valide Sultan Vakif Gureba Egitim ve Arastirma Hastanesi

Istanbul, 34093, Turkey (Türkiye)
Brussels - UNIV Saint-Luc

Brussels, 1200, Belgium
Buenos Aires Skin S.A.

CABA, C1055AA0, Argentina
Center for Skin Research, Testing and Product Development

Makati City, 1229, Philippines
Centro de Investigación de Enfermedades Autoinmunes S.C.

Guadalajara, 44610, Mexico
Chang Gung Medical Foundation (CGMF) - Linkou Bran

Linkou District, 333, Taiwan
Charles Nicolle Hospital

Tunis, 1008, Tunisia
Clínica Dermacross S.A.

Vitacura, 7640881, Chile
Erasmus Medisch Centrum

Rotterdam, 3015 GD, Netherlands
FSBEI HE "Kirov State Medical University"

Kirov, 610035, Russia
Fachklinik Bad Bentheim

Bad Bentheim, 48455, Germany
Farhat Hached Hospital

Sousse, 4000, Tunisia
General Hospital of Thessaloniki "Ippokrateio"

Thessaloniki, 54643, Greece
HCMC Hospital of Dermato-Venereology

Ho Chi Minh City, 70000, Vietnam
HOP Saint-Louis

Paris, 75010, France
HOP l'Archet

Nice, 06200, France
Habib Thameur Hospital

Tunis, 1008, Tunisia
Hedi Chaker Hospital, Department of Dermatology

Sfax, 1053, Tunisia
Hospital Italiano de Buenos Aires

CABA, C1056AB, Argentina
Hospital Kuala Lumpur

Kuala Lumpur, 50586, Malaysia
Hospital Pakar Sultanah Fatimah

Muar town, 84000, Malaysia
Hospital Pulau Pinang

Pulau Pinang, 10990, Malaysia
Hospital Raja Permaisuri Bainun

Ipoh, 30450, Malaysia
Hospital Sant Joan de Déu

Esplugues Del Llobregat, 08950, Spain
Hospital Sultan Ismail

Johor Bahru, 81100, Malaysia
Hospital Sultanah Aminah

Johor Bahru, 80100, Malaysia
Hospital Universitario 12 de Octubre

Madrid, 28041, Spain
Hospital Universitario Dr Jose Eleuterio Gonzalez

Monterrey, 64460, Mexico
Huashan Hospital, Fudan University

Shanghai, 200040, China
Iloilo Doctors Hospital

Iloilo City, Iloilo, 5000, Philippines
Institute of Dermatology

Bangkok, 10400, Thailand
Istanbul Universitesi Cerrahpasa Tip Fakultesi

Istanbul, 34098, Turkey (Türkiye)
Istituto Clinico Humanitas

Rozzano (MI), 20089, Italy
King Chulalongkorn Memorial Hospital

Bangkok, 10330, Thailand
Klinikum Oldenburg AöR

Oldenburg, 26133, Germany
Klinikum der Universität München - Campus Innenstadt

München, 80337, Germany
Kyushu Rosai Hospital

Fukuoka, Kitakyushu, 800-0296, Japan
LLC "Avrora Medfort"

Saint Petersburg, 194156, Russia
LLC "Medical Center Azbuka Zdorovia"

Kazan', 420111, Russia
LLC Skin Disease Clinic of Pier Volkenstein, St. Petersburg

Saint Petersburg, 190123, Russia
La Rabta Hospital

Tunis, 1007, Tunisia
Marmara Universitesi Tip Fakultesi

Istanbul, 34460, Turkey (Türkiye)
Nagoya City University Hospital

Aichi, Nagoya, 467-8602, Japan
National Hospital of Dermatology and Venereology

Hà Nội, 10000, Vietnam
National Taiwan University Hospital

Taipei, 10002, Taiwan
Oakland Hills Dermatology

Auburn Hills, Michigan, 48326, United States
Pusan National Univ. Hosp

Busan, 49241, South Korea
Queen Elizabeth Hospital

Kota Kinabalu, 88586, Malaysia
Ramathibodi Hospital

Ratchatewi, Bangkok, 10400, Thailand
SBHI Chelyabinsk Reg.Clin.Derma.Dispen.

Chelyabinsk, 454048, Russia
Saitama Medical University Hospital

Saitama, Iruma-gun, 350-0495, Japan
Saratov State Med.Univ.n.a.Razumovskogo

Saratov, 410028, Russia
Sarawak General Hospital

Kuching, Sarawak, 93586, Malaysia
Second Affiliated Hospital of Xi'an JiaoTong University

Xi'an, 710004, China
Severance Hospital

Seoul, 03722, South Korea
Shanghai Skin Disease Hospital

Shanghai, 200000, China
Southern Philippines Medical Center

Davao City, 8000, Philippines
Sun yet-sen Memorial Hospital, Sun yet-sen Univesity

Guangzhou, 510288, China
The First Hospital of China Medical University

Shenyang, 110001, China
The Second Affiliated Hospital Zhejiang University School of Medicine

Hangzhou, 310009, China
Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital

Tianjin, 300120, China
Tokyo Medical University Hachioji Medical Center

Tokyo, Hachioji, 193-0998, Japan
Tokyo Medical University Hospital

Tokyo, Shinjuku-ku, 160-0023, Japan
Tokyo Medical University Ibaraki Medical Center

Ibaraki, Inashiki-gun, 300-0395, Japan
Uludag University Medicine Faculty Departmant of Dermatology

Bursa, 16059, Turkey (Türkiye)
Universitätsklinikum Bonn AöR

Bonn, 53127, Germany
Universitätsklinikum Frankfurt

Frankfurt am Main, 60596, Germany
Universitätsklinikum Münster

Münster, 48149, Germany
Universitätsklinikum Würzburg AÖR

Würzburg, 97080, Germany
Washington University School of Medicine

St Louis, Missouri, 63108, United States

Conditions

Explore the condition pages connected to this study.

GENERALIZED PUSTULAR PSORIASIS