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Love hormone may help social anxiety sufferers unlearn fear

NCT ID NCT05968651

Knowledge-focused Sponsor: University of Washington Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether oxytocin nasal spray helps people with social anxiety disorder learn safety from watching others. About 120 adults received either oxytocin or a placebo and underwent brain scans. The goal was to see if oxytocin improves the brain's ability to tell threat from safety cues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

121 people

The number who actually took part.

Started

Jun 2023

Finished

Sep 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: For Clinical Sample * Men and women age 18-45 * Women must be having regular menstrual cycles and not be taking oral contraception * Primary diagnosis of social anxiety disorder For Healthy Sample * Men and women age 18-45 * Women must be having regular menstrual cycles and not be taking oral contraception * No current or lifetime history of psychiatric, neurological, or medical disorders Exclusion Criteria: For All Groups * Pregnancy or breastfeeding * Positive urine drug screening test result * History of nasal pathology * Current use of any psychotropic medication or steroids * Active substance use disorder within the past 6 months * History of serious medical illnesses or untreated endocrine diseases * History of head injury, neurological disorder, or neurosurgical procedure * Positive magnetic resonance (MR) screen For Clinical Sample * Lifetime diagnoses of mania or psychotic disorder based on the Diagnostic and Statistical Manual (DSM- 5th ed) * Acute suicidal ideation For Healthy Sample * Lifetime DSM-5 diagnosis of any medical, neurological, or psychiatric illness

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Conditions

The condition(s) this trial relates to.

social phobia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Social phobia

Contacts and locations

Locations

  • University of Washington

    Seattle, Washington, 98195, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.