New steerable wire aims to simplify brain aneurysm repair
NCT ID NCT05564325
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a new steerable guidewire called SmartGUIDE for treating unruptured brain aneurysms. The wire has a bendable tip that doctors can control during the procedure, potentially making it easier to reach the aneurysm. Only 5 people took part before the study was stopped early, so we have very little data on how well it works.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- SmartGUIDE deflectable guidewire (device)
- What this could lead to
- If successful, this steerable guidewire could make aneurysm coiling procedures easier and faster for doctors.
- What could go wrong
- The trial was terminated early with only 5 participants, so results are very limited. It is unclear if the device works better than standard guidewires.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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5 people
The number who actually took part.
- Started
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Apr 2023
- Finished
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Mar 2026
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * \>18 years of age * Informed consent signed by patient * Confirmed cerebral unruptured aneurysm treatable via transcatheter approach Exclusion Criteria: * Pregnancy or lactation * Known disorder of vascular fragility with propensity to vascular injury (e.g., Ehlers-Danlos syndrome) * Known prior vascular stenosis or dissection or injury to vessels intended to be catheterized during study procedures * Acute phase myocardial infarction or uncontrolled cardiac arrhythmia * Uncontrolled serum electrolyte imbalance * Bleeding disorder which limits the use of antiplatelet and/or anticoagulant therapy * Known contraindication to intravascular contrast material that cannot be adequately controlled with pre-medication * Known hypersensitivity to Nickel * Subjects currently enrolled in another investigational device or drug study that clinically interferes with the current study endpoints
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Geneva University Hospital - HUG
Geneva, Switzerland
More trials for these conditions
Other studies related to the condition(s) this trial covers.