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New hope for kids with rare cancer: drug combo shows promise

NCT ID NCT06341998

First seen Sep 30, 2025 · Last updated Jun 16, 2026 · Updated 33 times

Summary

This study tested a new combination of the drug sirolimus plus chemotherapy (nab-paclitaxel, ifosfamide, and carboplatin) in 32 children with recurrent or treatment-resistant yolk sac tumor. The goal was to see if the combo could shrink tumors and improve survival. The study is complete, and results will show how well the treatment worked and how safe it was.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Shandong Cancer Hospital and Institute

    Jinan, Shandong, 250117, China

Conditions

The condition(s) this trial relates to.

Endodermal Sinus Tumor germ cell tumor Neoplasms, Germ Cell and Embryonal yolk sac tumor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.