New drug SIBP-A10 tested in patients with advanced cancer

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Voluntarily participate in this study and sign an informed consent form; * Age range of 18 to 75 years old (including boundary values), gender not limited; * The clinical diagnosis of enrolled subjects should meet the conditions specified in the protocol: * There must be at least one measurable lesion as the target lesion; * Backfilling queue during dose escalation stage, dose expansion stage, and indication expansion stage: able to provide tumor tissue samples that meet the requirements of the protocol or undergo tumor biopsy during screening, or provide testing reports issued by legitimate testing institutions that meet the requirements; * I have not received any medication targeting Siglec-15 in the past; * The Eastern Cooperative Oncology Group (ECOG) physical fitness score ranges from 0 to 1; * Expected survival period ≥ 3 months; * During the screening period, the main organ functions were basically normal; * During the screening period, women of childbearing age had negative blood pregnancy tests, and reproductive age subjects (including male subjects) had no pregnancy plans during the trial period and within 6 months after the last dose, and voluntarily took effective contraceptive measures. Exclusion Criteria: * The subject has the following tumors: * The subject has had other malignant tumors that have not healed within the past 5 years; * Subjects with meningeal metastases; * Subjects with active brain metastases; * For anti-tumor subjects with a history of past treatment or surgery that does not comply with the protocol, or who have received treatment that does not comply with the protocol during the planned trial period * Previous medical history or laboratory non-compliance with protocol requirements * According to the researchers' assessment, the screening period is accompanied by severe, progressive, or uncontrolled non-tumor diseases, and it has been determined by the researchers that participating in the study would increase the risk for the subjects. * According to the investigator's judgment, there are concomitant diseases (including but not limited to hypertension, diabetes, active infection, etc. that cannot be controlled by drugs) that seriously endanger the patient's safety or affect the patient's completion of the study * Researchers determine that there are uncontrollable ascites, pleural effusion, or pericardial effusion, or those who have undergone ≥ 2 serosal drainage within 2 weeks prior to the first administration; * Before starting treatment, the patient has not yet recovered to ≤ grade 1 from the toxic effects of previous treatments (including previous immunotherapy) and/or complications of previous surgical interventions. * Individuals with a history of severe allergies to protein products, CHO cell products, other recombinant human or humanized antibodies, or components of the investigational drug; * Pregnant and lactating women; * Researchers believe that subjects who are not suitable to participate in this clinical study due to other reasons.