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Sound waves vs. radiation damage: new hope for bladder pain?

NCT ID NCT07016451

Symptom relief Sponsor: Thanakrit Visuthikosol Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed early-phase trial tested whether low-intensity shockwave therapy (Li-ESWT) can ease symptoms of radiation cystitis, a painful bladder condition from pelvic radiation. Twenty-five adults who had radiation at least six months prior were enrolled. The study compared shockwave treatment to standard medications, tracking changes in urinary symptoms and bladder inflammation markers.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Low-intensity extracorporeal shock wave therapy (Li-ESWT)
What this could lead to
If it works, this could offer a new, non-drug option to ease bladder pain and urinary symptoms caused by past radiation therapy.
What could go wrong
This is a very early, small trial with only 25 people. The results may not apply to everyone, and the treatment might not work better than standard medications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

25 people

The number who actually took part.

Started

Apr 2024

Finished

Mar 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Criteria for diagnosis of radiation-induced cystitis and a history of pelvic radiation therapy administered more than 6 months prior. * Aged 18 years or older. * Willing to participate in the research study by providing written informed consent. Exclusion Criteria: * Active urinary tract infection within the past 6 months. * Active and uncontrolled gross hematuria. * Patients currently have a urinary diversion or abdominal ostomy. * Patients with anuria due to chronic kidney failure. * Uncontrolled coagulopathy. * Refuse participation, withdraw from the study, or experience severe adverse effects.

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Conditions

The condition(s) this trial relates to.

radiation cystitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Radiation cystitis

Contacts and locations

Locations

  • Ramathibodi Hospital

    Bangkok, 10400, Thailand

More trials for these conditions

Other studies related to the condition(s) this trial covers.