Gene therapy aims to calm deadly heart rhythm disorder in first human test
NCT ID NCT07148089
First seen Oct 31, 2025 · Last updated May 20, 2026 · Updated 27 times
Summary
This early-stage study tests the safety of a single dose of SGT-501, a gene therapy for people with catecholaminergic polymorphic ventricular tachycardia (CPVT), a rare inherited heart condition that can cause dangerous heart rhythms during exercise or stress. Up to 18 adults and children (ages 7 and older) will receive the treatment and be monitored for 5 years. The main goal is to check for side effects, with a secondary look at whether the therapy reduces abnormal heartbeats during exercise testing.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Study contacts
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Locations
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Boston Children's Hospital
RECRUITINGBoston, Massachusetts, 02459, United States
Contact Email: •••••@•••••
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Cleveland Clinic
RECRUITINGCleveland, Ohio, 44195, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Mayo Clinic
RECRUITINGRochester, Minnesota, 55905, United States
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St. Paul's Hospital
RECRUITINGVancouver, British Columbia, BC V6Z 1Y6, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Pennsylvania
NOT_YET_RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Conditions
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