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Grip strength study reveals sex differences in blood pressure control

NCT ID NCT06215014

Knowledge-focused Sponsor: University of Massachusetts, Boston Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether young men and women respond differently to a simple handgrip exercise for lowering blood pressure. Twenty-nine healthy adults did handgrip training at home for 4 weeks, while researchers measured blood pressure and blood vessel function. The goal is to understand if sex plays a role in how well this type of exercise works.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
isometric handgrip exercise training
What this could lead to
If successful, this could help tailor exercise recommendations for blood pressure management based on sex.
What could go wrong
This is a small, early-stage study with only 29 healthy participants, so results may not apply to people with high blood pressure or other conditions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

29 people

The number who actually took part.

Started

Mar 2024

Finished

Jun 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Ages between 18-40 years; * Normal blood pressure as defined by the American Heart Association (\<130/90 mmHg); * BMI \< 30 kg/m2; * No cardiovascular risk factors and no clinically diagnosed cardiovascular disease; * Being recreationally active (≤ 2 days of structured physical activity); * Able to speak English. Exclusion Criteria: * Diagnosed with cardiovascular disease (e.g., coronary artery disease, heart failure), musculoskeletal (i.e., osteoporosis and sarcopenia), metabolic disease (e.g., diabetes mellitus) and kidney disease; * Taking antihypertensive or other vasoactive medications and cardioactive medication; * Diagnosed with depression and/or anxiety disorders; * Long COVID; * Being a smoker; * Being pregnant or having menstrual irregularities.

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Conditions

The condition(s) this trial relates to.

hypertensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Blood pressure

Contacts and locations

Locations

  • UMassachusetts Boston

    Boston, Massachusetts, 02125, United States

  • University of Massachusetts Boston

    Boston, Massachusetts, 02125, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.