Blood bicarbonate levels may predict feeding issues in ICU patients
NCT ID NCT07518095
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study will check if low bicarbonate levels in the blood can predict when adult ICU patients will have trouble with tube feeding. Researchers will watch 70 patients for 72 hours after they start feeding. The goal is to find a simple way to identify patients at risk, so doctors can act early.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 70 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Apr 2026
An estimate. Start dates often move.
- Expected to finish
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Jan 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The study population consists of adult patients aged 18 and older who are admitted to the intensive care unit (ICU). This group specifically includes those who begin enteral nutrition (EN) within the first 48 hours of their ICU admission and are expected to remain in the unit for at least 72 hours. The target sample size is 70 participants, factoring in potential drop-outs to maintain statistical power. Certain clinical conditions are excluded to ensure data consistency, such as pregnancy, 18 years of age or younger, active gastrointestinal bleeding or perforation, and recent major abdominal surgery. Additionally, patients requiring specialized enteral formulas or those with advanced organ failure (e.g., Child-Pugh C liver failure or dialysis-dependent kidney failure) are not included in the study population.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adult patients aged 18 and older. * Patients started on enteral nutrition (EN) within the first 48 hours of their intensive care unit admission. * Patients predicted to remain in the intensive care unit for at least 72 hours. * Patients (or their legal representatives) who have provided consent to participate in the study. Exclusion Criteria: * Patients under the age of 18.Individuals who are currently pregnant or breastfeeding. * Patients with gastrointestinal (GI) perforation, active GI bleeding, or mechanical bowel obstruction. * Patients who have undergone major abdominal surgery (e.g., esophagectomy, gastrectomy) within the last month. * Patients receiving total parenteral nutrition (TPN) or those who are only fed orally. * Patients requiring specialized enteral formulas (e.g., diabetic, renal, immunomodulatory, elemental, or semi-elemental) due to clinical necessity. * Patients with a known diagnosis of diabetes or those with HbA1c \>6.5 requiring a diabetic enteral formula. * Patients with terminal-stage malignancy or those requiring specific enteral nutrition protocols. * Patients with advanced (Child-Pugh C) liver failure. * Patients with chronic kidney failure requiring dialysis. * Patients with diabetic ketoacidosis, severe metabolic asidozis, or those requiring initial bicarbonate replacement. * Patients who are brain dead or in the palliative care stage.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Istinye Üniversity
Istanbul, Merkez Mahallesi, 34250, Turkey (Türkiye)
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