New Two-Drug combo aims to control chronic hepatitis b

NCT ID NCT05276297

Completed Disease control Sponsor: GlaxoSmithKline Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 25, 2026 · Updated 27 times

Summary

This study tested a new two-step treatment for adults with chronic hepatitis B who are already on standard antiviral pills. First, participants received an experimental drug (ASO) for 12 or 24 weeks, followed by a targeted immunotherapy. The goal was to see if this sequence could better control the virus and reduce side effects. 174 adults aged 18-65 took part, and researchers monitored safety and how well the virus was suppressed.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

GSK Investigational Site

Edegem, 2650, Belgium
GSK Investigational Site

Sliven, 8800, Bulgaria
GSK Investigational Site

Sofia, 1407, Bulgaria
GSK Investigational Site

Sofia, 1431, Bulgaria
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Sofia, 1784, Bulgaria
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Sofia, 1797, Bulgaria
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Veliko Tarnovo, 5000, Bulgaria
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Vratsa, 3000, Bulgaria
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Clichy, 92118, France
GSK Investigational Site

Créteil, 94010, France
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Lyon, 69317, France
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Strasbourg, 67091, France
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Berlin, 10787, Germany
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Frankfurt, 60590, Germany
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Leipzig, 04103, Germany
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Pokfulam, Hong Kong
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Bergamo, Italy
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Milan, 20122, Italy
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Milan, 20157, Italy
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Roma, 00133, Italy
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Rozzano MI, 20089, Italy
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Makati City, 1229, Philippines
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Pasig, 1605, Philippines
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Krakow, 31-202, Poland
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Mysłowice, 41-400, Poland
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Łańcut, 37-100, Poland
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Cluj-Napoca, 400162, Romania
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Craiova Dolj, 200515, Romania
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Singapore, 119074, Singapore
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Singapore, 169608, Singapore
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Barcelona, 08011, Spain
GSK Investigational Site

Madrid, 28006, Spain
GSK Investigational Site

Madrid, 28007, Spain
GSK Investigational Site

Madrid, 28034, Spain
GSK Investigational Site

Madrid, 28046, Spain
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Madrid, 28222, Spain
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Santander, 39008, Spain
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Seville, 41013, Spain
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Vigo, 36071, Spain
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Chiayi City, 600, Taiwan
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Kaohsiung City, 807, Taiwan
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Linkou - Taoyuan Hsien, 333, Taiwan
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Taichung, 404, Taiwan
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Taichung, 40705, Taiwan
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Tainan, 704, Taiwan
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Bangkok, 10330, Thailand
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Chiang Mai, 50200, Thailand
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Istanbul, 6690, Turkey (Türkiye)
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Rize, 53200, Turkey (Türkiye)
GSK Investigational Site

Cottingham, HU16 5JQ, United Kingdom
GSK Investigational Site

Leicester, LE1 5WW, United Kingdom

Conditions

Explore the condition pages connected to this study.

HEPATITIS B, CHRONIC