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Brain scans reveal why tourette patients are hypersensitive to everyday stimuli

NCT ID NCT03914664

Knowledge-focused Sponsor: Vanderbilt University Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study aims to understand why many people with Tourette syndrome are overly sensitive to everyday sensations like touch or noise. Researchers will monitor brain activity, heart rate, and sweat responses in 50 adults with Tourette syndrome while they experience different sounds and touches. No treatment is given; the goal is to learn more about the condition to guide future therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2021

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The two groups of participants will include: 1. adult with Tourette syndrome or other chronic tic disorder 2. healthy controls

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria for TS arm: * Diagnosis of Tourette syndrome or other chronic tic disorder * ≥ 18 years of age * Ability to complete survey instruments * English fluency (given that all scales are validated in English) Exclusion criteria for TS arm: \- Known diagnosis of autism spectrum disorder, developmental delay, cerebral palsy, other significant neurologic disease, schizophrenia, or psychotic disorders will be excluded, in order to lessen potentially confounding factors. (Note: Patients with OCD, ADHD, anxiety, and/or depression will be permitted, given that these diagnoses are widely prevalent in the adult TS population.) * Use of anti-seizure medications, stimulants, or other psychotropic medications known to alter EEG signal * Recreational substance use within past 30 days Inclusion criteria for healthy control arm: * ≥ 18 years of age AND age within 5 years of a participant in the TS arm of same biological sex (for purposes of age- and sex-matching) * Ability to complete survey instruments * English fluency (given that all scales are validated in English) Exclusion criteria for healthy control arm: * Any neurologic or psychiatric diagnoses * History of tics * Use of any psychotropic medications within the past 30 days * Recreational substance use within past 30 days

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Conditions

The condition(s) this trial relates to.

allergic disease chronic tic disorder hypersensitivity reaction disease Sensation Disorders Tics Tourette syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hypersensitivity Sensory disorders Tics Tourette syndrome

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232-5400, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.