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AI learns to read pain from faces and voices in new cancer study

NCT ID NCT07262632

Knowledge-focused Sponsor: Dr. Mark Mulder Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is collecting short video and voice recordings from 200 cancer patients—some in pain, some not—to create a secure database. The goal is to provide raw material for future artificial intelligence tools that could automatically assess pain from facial expressions and speech. No treatments or medical tests are involved; participants simply read a sentence and describe their experience while being recorded.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this database could help researchers develop an AI tool that automatically detects pain from facial expressions and voice, making pain assessment easier and more objective.
What could go wrong
This is an early data-collection study, not a treatment trial. The AI tool is not being tested yet, and it may take years to develop or may not work as hoped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2025

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Hospitalised adult cancer patients recruited from the oncology and palliative care departments of Erasmus University Medical Center (Erasmus MC) in Rotterdam, the Netherlands. The study includes both patients admitted for cancer-related pain and those admitted for treatment without pain. Participants represent an inpatient clinical population from a tertiary referral centre, providing a controlled setting for audiovisual and clinical data collection.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients (≥18 years) * Diagnosed with cancer, active * Able to communicate verbally in Dutch or English * Able to provide written informed consent. * Pain group specific: * Experiencing pain related to cancer * Admitted to the hospital due to pain * Control group specific: * Not experiencing pain (NRS = 0) * Admitted to the hospital for chemotherapy Exclusion Criteria: * Cognitive, physical, or medical limitations that prevent participation in the audiovisual recording sessions or affect facial expressions or voice (e.g. facial paralysis, tracheostomy, severe speech impairment). * Critical illness or end-of-life care where participation would impose an additional burden. * Experiencing pain not associated with cancer * Infectious isolation precautions that prevent safe data collection

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Conditions

The condition(s) this trial relates to.

cancer Cancer Pain Facial Expression neoplasm Vocalization, Animal voice disorders

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Artificial intelligence (AI) Cancer Cancer-related pain Database Facial expression Oncology Oncology pain Pain assessment VOICE

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Erasmus University Medical Centre

    RECRUITING

    Rotterdam, South Holland, 3015 GD, Netherlands

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