Diabetes drug semaglutide put to the test in chilean patients
NCT ID NCT05533632
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested the safety and tolerability of a once-weekly injection of semaglutide (0.5 or 1.0 mg) in 104 Chilean adults with type 2 diabetes over 24 weeks. Participants received the drug in escalating doses, with regular blood and urine tests to monitor side effects. The main goal was to count any adverse events, while also tracking changes in blood sugar control (HbA1c).
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- semaglutide (a once-weekly injection for diabetes)
- What this could lead to
- If successful, this study could confirm that semaglutide is safe and well-tolerated for managing type 2 diabetes in Chilean patients.
- What could go wrong
- This is a small, completed Phase 4 safety study, not designed to prove major new benefits. Results may not apply to other populations or show unexpected side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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104 people
The number who actually took part.
- Started
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Apr 2022
- Finished
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Jan 2024
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Participants diagnosed (clinically) with type 2 diabetes greater than equal to (≥) 90 days prior to the screening visit. * Stable daily dose of Oral Antidiabetic Drug (OAD) and/or insulin treatment for ≥ 60 days prior to the screening visit. * HbA1c 7.5-10% (59-86 millimoles per mole \[mmol/mol\]) (both inclusive) in Visit 1. * Participants in which Ozempic is indicated according to approved local label. * Fundoscopy/Fundus photography record less than equal to (≤) 12 months. Exclusion Criteria: * Known or suspected hypersensitivity to study intervention(s) or related products. * Previous participation in this study. Participation is defined as signed informed consent. * Female who is pregnant, breast-feeding or intends to become pregnant or is of childbearing potential and not using adequate contraceptive method. * Participation in any clinical trial of an approved or non-approved investigational medicinal product within 30 days before the screening visit, except Coronavirus Disease 2019 (COVID-19) related trials (this is allowed). * Treatment with any glucagon-like peptide-1 receptor agonists (GLP-1 RA) medication prior to the screening visit. * Any disorder which in the investigator's opinion might jeopardise participant's safety or compliance with the protocol. * Family or personal history of Multiple Endocrine Neoplasia Type 2 or Medullary Thyroid Carcinoma. * History of pancreatitis (acute or chronic). * Renal impairment defined as estimated glomerular filtration rate (eGFR) below 30 milliliters/minute (mL/min)/1.73 meter square (m\^2) as per MDRD-4 (Modification of Diet in Renal Disease). * Myocardial infarction, stroke or hospitalisation for unstable angina or transient ischaemic attack within the past 180 days prior to the day of screening. * Participants presently classified as being in New York Heart Association (NYHA) Class IV heart failure. * Planned coronary, carotid or peripheral artery revascularisation known on the day of screening. * Participants with alanine aminotransferase (ALT) \> 2.5 x upper normal limit (UNL). * Use of systemic immunosuppressive treatment within 90 days prior to screening. * Treatment with any medication for the indication of diabetes or obesity other than stated in the inclusion criteria in a period of 90 days before the day of screening. An exception is short-term insulin treatment for acute illness for a total of ≤ 14 days. * Known hypoglycaemic unawareness and/or recurrent severe hypoglycaemic episodes as judged by the investigator. * Proliferative retinopathy or maculopathy requiring acute treatment. Verified by fundus photography or dilated fundoscopy performed within 12 months prior to screening. * History or presence of malignant neoplasms within the last 5 years (except basal and squamous cell skin cancer and carcinoma in situ).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Hospital Padre Hurtado
Santiago, Región Metropolitana, 8880465, Chile
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Hospital San Juan de Dios_Santiago, Región Metropolitana
Santiago, Región Metropolitana, 8350429, Chile
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Servicios Médicos Godoy Limitada
Santiago, Región Metropolitana, 7500710, Chile
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