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Which sedative is safer for emergency intubation? major trial reveals key insights

NCT ID NCT05277896

First seen Sep 30, 2025 · Last updated Jun 18, 2026 · Updated 34 times

Summary

This study looked at over 2,300 critically ill adults who needed an emergency breathing tube. Doctors wanted to know if using ketamine or etomidate as a sedative leads to better outcomes, like survival and fewer heart problems. The goal was to find out which medicine is safer for this high-risk procedure.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Denver Health Medical Center

    Denver, Colorado, 80204, United States

  • Hennepin County Medical Center

    Minneapolis, Minnesota, 55415, United States

  • UAB Hospital

    Birmingham, Alabama, 35233, United States

  • University of Colorado Denver

    Aurora, Colorado, 80045, United States

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232, United States

  • Wake Forest Baptist Medical Center

    Winston-Salem, North Carolina, 27157, United States

Conditions

The condition(s) this trial relates to.

acute respiratory failure Critical Illness

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.