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Numbing the scalp may beat opioids for brain surgery pain

NCT ID NCT07425678

Symptom relief Sponsor: Aga Khan University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a scalp nerve block (injecting numbing medicine into the scalp) controls pain better than morphine during and after brain surgery. 62 adults having brain tumor surgery were randomly assigned to receive either a scalp block or morphine. Researchers measured heart rate, blood pressure, pain scores, and opioid use. The goal is to find a safer, more effective way to manage pain and reduce opioid-related side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
scalp nerve block (injection of lidocaine and ropivacaine) versus morphine
What this could lead to
If scalp nerve block works better, it could offer a safer way to manage pain during brain surgery, reducing opioid side effects and speeding recovery.
What could go wrong
This is a small, completed Phase 4 trial with only 62 participants. Results may not apply to all patients or settings, and nerve blocks carry their own risks like infection or incomplete pain relief.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

62 people

The number who actually took part.

Started

Jan 2025

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 years to 75 years, * American Society of Anesthesiologists class I-III, * Scheduled for supratentorial craniotomy. Exclusion Criteria: * Patient with Glasgow Coma Score (GCS) of less than 15, * Inability to understand the Visual analog scale (VAS) * Allergic to study drugs (Morphine and local anesthetics) * Patient chronically treated with narcotic medications. * History of Liver dysfunction

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Conditions

The condition(s) this trial relates to.

supratentorial cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Supratentorial tumors

Contacts and locations

Locations

  • Aga Khan University Hospital

    Karachi, Sindh, 74800, Pakistan