New pill aims to slow lung scarring in IPF patients
NCT ID NCT06747923
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests an experimental drug called SB17170 in 30 adults with moderate to severe idiopathic pulmonary fibrosis (IPF), a disease that scars the lungs and makes breathing hard. Participants take either the drug or a placebo daily for 12 weeks. The main goal is to see if the drug improves lung function, measured by how much air they can exhale.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- SB17170 (an experimental oral drug)
- What this could lead to
- If successful, this could point toward a new treatment option to slow lung function decline in people with idiopathic pulmonary fibrosis.
- What could go wrong
- This is an early Phase 2a trial with only 30 participants, so results may not apply broadly. The drug may not improve lung function or could cause side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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About 30 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jan 2025
- Expected to finish
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Oct 2026
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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40 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Adult male/female 40 years or older at the time of obtaining informed consent 2. Patients diagnosed with idiopathic pulmonary fibrosis who meet the following criteria: * Patients with idiopathic pulmonary fibrosis who are confirmed by chest High-Resolution Computed Tomography (HRCT) scan * Patients with Usual Interstitial Pneumonia (UIP) or probable UIP HRCT pattern consistent with a diagnosis of idiopathic pulmonary fibrosis confirmed through central reading of chest HRCT before the baseline visit 3. Patients with a history of idiopathic pulmonary fibrosis treatment who meet the defined criteria 4. Patients with Forced Vital Capacity (FVC) ≥ 45% of the normal predicted value at the screening visit 5. Patients meeting pulmonary function test criteria at the screening visit 6. Patients who have received the explanation of this clinical trial and voluntarily agreed and signed the informed consent form Exclusion Criteria: 1. When there is a primary disease showing UIP patterns (rheumatoid arthritis-related interstitial lung disease, connective tissue disease-related interstitial lung disease, etc.) and/or other clinically significant lung abnormalities 2. Patients with confirmed acute exacerbation of IPF within 6 months prior to screening and/or during the screening period 3. Patients with lower respiratory tract infections requiring antibiotic treatment 4. Patients who underwent major surgery within 3 months before screening or have major surgery planned during the clinical trial 5. Patients with a history of malignancy or documented evidence of active or suspected malignancy within 5 years prior to screening 6. Patients with evidence of active infection 7. Patients with the following cardiovascular and cerebrovascular diseases at the time of screening: * Severe hypertension within 3 months * Myocardial infarction or unstable angina within 6 months * History of thrombotic events within 6 months * Diagnosis of heart failure within 6 months 8. Patients with pulmonary hypertension 9. Patients who are unable to take drugs orally or have a history of major gastrointestinal surgery or pathological findings that may affect the absorption of the investigational product 10. Patients with Human Immunodeficiency Virus (HIV) infection or active hepatitis B or C
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
5 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Ajou University Hospital
NOT_YET_RECRUITINGSuwon, South Korea
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Chung-Ang University Gwangmyeong Hospital
RECRUITINGGwangmyeong, South Korea
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Myong Ji Hospital
RECRUITINGGoyang, South Korea
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Seoul Asan Hospital
NOT_YET_RECRUITINGSeoul, South Korea
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The Catholic Univ. of Korea Seoul St. Mary's Hospital
NOT_YET_RECRUITINGSeoul, South Korea
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Patients and families build a living database of pulmonary fibrosis
- Can pulmonary fibrosis patients pull hard enough for their inhalers?
- Can a thousand patient records unlock better care for a rare lung disease?
- Sharper CT scans may solve a lung disease diagnostic puzzle
- Can we untangle the overlap of lung diseases? a new study aims to find out
- A blood test that could predict who survives a lung disease crisis?