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Mouth's natural defenders may hold key to Kids' cavities

NCT ID NCT07414030

Knowledge-focused Sponsor: Bezmialem Vakif University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 18, 2026 · Updated 2 times

Summary

This study looked at whether certain natural proteins in saliva are linked to severe tooth decay in young children. Researchers compared 50 Turkish children aged 3-6 with and without severe cavities. They measured levels of antimicrobial peptides in saliva to see if differences exist between the groups. The goal is to better understand why some children get severe cavities.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could point toward new ways to predict or prevent severe cavities in young children.
What could go wrong
This is a small, completed observational study, not a treatment trial. It only shows possible links, not cause and effect, and may not apply to other populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

50 people

The number who actually took part.

Started

Jul 2024

Finished

Sep 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consisted of systemically healthy Turkish children aged 3-6 years who attended the pediatric dentistry clinic. Participants were divided into two groups: children diagnosed with severe early childhood caries (S-ECC) and caries-free controls.

Ages

3 to 6 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Case Group (S-ECC): * Preschool children aged 3-6 years * In the primary dentition period * No previous history of dental treatment * Diagnosis of severe early childhood caries (S-ECC) defined as: dmft ≥4 at age 3, dmft ≥5 at age 4, dmft ≥6 at age 5 * Systemically healthy children * Turkish ethnicity * Written informed consent obtained from parents or legal guardians Control Group: * Preschool children aged 3-6 years * In the primary dentition period * No previous history of dental treatment * Caries-free children (dmft = 0) * No history of fillings or tooth extraction due to caries * Systemically healthy children * Turkish ethnicity * Written informed consent obtained from parents or legal guardians Exclusion Criteria: * Use of medications affecting salivary flow within the last 3 months (e.g., antimuscarinic agents, antihypertensives, antidepressants) * Presence of systemic or local diseases affecting salivary secretion (e.g., diabetes, salivary gland infections, salivary gland stones, neurological disorders) * Lack of parental/legal guardian consent * Inability to cooperate during saliva sample collection * Presence of chronic systemic diseases * History of chemotherapy or radiotherapy

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Conditions

The condition(s) this trial relates to.

dental caries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dental caries Severe early childhood caries

Contacts and locations

Locations

  • Bezmialem Vakif University Faculty of Dentistry, Department of Pediatric Dentistry

    Istanbul, 34093, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.