Saliva secrets: could proteins tell two mouth diseases apart?
NCT ID NCT07416318
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at saliva from 21 people: some with oral lichen planus, some with oral leukoplakia, and some healthy. The goal was to see if proteins in saliva are different between these groups. Researchers hope these protein differences could one day help doctors tell these two mouth conditions apart without a biopsy.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
-
21 people
The number who actually took part.
- Started
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Dec 2024
- Finished
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Apr 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The study population consists of individuals diagnosed with Oral Lichen Planus (OLP), individuals diagnosed with Oral Leukoplakia (OL), and healthy volunteers without oral mucosal disease. Participants were recruited from patients presenting for clinical evaluation and routine care, and were assigned to one of three cohorts based on clinical examination and diagnosis. The control group included individuals with clinically normal oral mucosa and no history of oral mucosal pathology.
- Ages
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29 to 71 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Saliva samples from patients diagnosed with either OLP or OL were included in the study group. * Saliva samples from individuals with no dermatological or systemic diseases and no lesions in the oral mucosa were included in the control group. Exclusion Criteria: * Patients who were using corticosteroids or retinoids that could affect the mucosa either locally or systemically were excluded from the study. * Patients with hyposalivation or with any conditions or medications that could cause reduced salivary flow were also excluded from the study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Kocaeli University
Kocaeli, Turkey (Türkiye)
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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