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Spit test for implant health? saliva study probes immune signals

NCT ID NCT07813845

Knowledge-focused Sponsor: Akdeniz University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 10, 2026 · Last updated Sep 11, 2026 · Updated 1 time

Summary

Researchers at Akdeniz University are studying whether saliva contains different levels of three markers, sIgA, MMP-8, and MMP-9, depending on a person's dental setup. The study compares 107 adults in four groups: people with healthy natural teeth, people with partial implant-supported bridges plus some natural teeth, people with full-arch fixed implant prostheses, and people with implant-retained overdentures. Participants give unstimulated saliva samples, and researchers measure the markers with lab tests. The goal is to see if these saliva signals relate to implant type and gum measurements like probing depth.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If saliva markers track with implant type or gum health, dentists could one day use a simple spit test to spot early implant problems instead of relying on probing alone.
What could go wrong
This is a small observational study that only measures markers at one point in time. It cannot show cause and effect, and the findings may not apply to other implant designs or patient groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

107 people

The number who actually took part.

Started

Aug 2025

Finished

Feb 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adults attending the Department of Prosthodontics, Faculty of Dentistry, Akdeniz University were recruited and classified according to their existing dentition and prosthetic status. The study population included periodontally healthy fully dentate individuals without implants and patients rehabilitated with implant-supported partial fixed prostheses, full-arch fixed implant-supported prostheses, or implant-retained overdentures. Prosthetic rehabilitation was present before enrollment and was not assigned by the study protocol.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 years or older. * Ability and willingness to provide written informed consent. * For the healthy dentate group: fully dentate individuals without dental implants who were systemically and periodontally healthy, with probing depths of 3 mm or less at all sites and full-mouth bleeding on probing below 10%. * For the implant groups: presence of an implant-supported partial fixed prosthesis, full-arch fixed implant-supported prosthesis, or implant-retained overdenture with osseointegrated implants restored with a definitive prosthesis in function for at least 6 months. Exclusion Criteria: * Antibiotic use within the preceding 6 months. * Periodontal therapy within the preceding 6 months. * Systemic conditions known to affect periodontal or immune status, including diabetes mellitus, cardiovascular disease, rheumatoid arthritis, systemic lupus erythematosus, or inflammatory bowel disease. * Systemic infectious diseases, including tuberculosis, hepatitis, or human immunodeficiency virus infection. * Mucocutaneous diseases affecting the oral mucosa, including lichen planus, pemphigus vulgaris, or chronic ulcerative stomatitis. * Ongoing systemic corticosteroid, immunosuppressant, or biologic therapy. * Pregnancy or lactation.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Peri-implant diseases

Contacts and locations

Locations

  • Akdeniz University Faculty of Dentistry

    Antalya, Antalya, 07058, Turkey (Türkiye)