Fever machine: could controlled heat be a new therapy?

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: \- A person who meets all of the following criteria will be eligible for this study: * Provision of signed and dated informed consent/assent form. * Ability to understand the nature of the study and protocol requirements and provide written informed consent. * Willingness to comply with all study procedures and availability for the duration of the study. * Aged over 18 years and no more than 65 years * Males and Female * Values of vital signs before BTT Hyperthermic Induction should be: * Systolic between 100-140 mm Hg o diastolic between 50-90 mm Hg * cardiac pulse between 45-90 beats per minute * Free from any treatment in the 7 days preceding inclusion including no use of analgesics or anti-inflammatory drugs) Exclusion Criteria: * History of Cardiovascular and venous thrombosis disorders * History of auto-immune disorders * History of pulmonary disease * History of Neurological disorders * History of Cancer disorders * Renal or Hepatic insufficiency * Medical history and / or surgical judged by the investigator or his representative as being incompatible with the test, especially subjects who do not support high fever range in the past during adult or childhood life. * Pathology evolutionary time of the review of inclusion * Excessive consumption of alcohol, tobacco (over 10 cigarettes / day), coffee, tea or drinks containing caffeine (equivalent to more than 4 cups per day) or drug abuse. * The person(s) with the following condition(s) are excluded to participate in the study 1. Implanted electronic devices 2. Any metal implant 3. Dermatological conditions sensitive to heat 4. Any enclosed infection that, as assessed by a qualified physician, serves as a contraindication for hyperthermia 5. Clinically significant ECG findings, as per determined by a cardiologist, including uncontrolled arrhythmia 6. A subject who in the opinion of the Principal Investigator would not be able to safely complete the study