New drug shows promise in advanced bladder cancer battle
NCT ID NCT04527991
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a new drug called sacituzumab govitecan against standard treatments in 711 people with advanced bladder cancer that had spread or couldn't be removed. The goal was to see if the new drug helped people live longer. Participants received either the new drug or a treatment chosen by their doctor.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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711 people
The number who actually took part.
- Started
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Jan 2021
- Finished
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Jul 2025
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Key Inclusion Criteria: * Individuals with histologically documented metastatic or locally advanced unresectable UC defined as * Tumor (T) 4b, any node (N) or * Any T, N 2-3 Tumors of upper and lower urinary tract are permitted. Mixed histologic types are allowed if urothelial is the predominant histology. * Eastern Cooperative Oncology Group (ECOG) performance status (PS) score of 0 or 1. * Individuals with progression or recurrence following receipt of platinum-containing regimen and anti programmed cell death protein 1/programmed death-ligand 1 (PD-1/PD-L1) therapy for metastatic or locally advanced unresectable disease will be enrolled. * Individuals with recurrence or progression ≤12 months following completion of cisplatin-containing chemotherapy given in the neo-adjuvant/adjuvant setting may utilize that line of therapy to be eligible for the study. The 12-month period is counted from completion of surgical intervention or platinum therapy, respectively. These individuals must receive anti PD-1/PD-L1 therapy in the metastatic or locally advanced unresectable setting to be eligible. * Individuals who received either carboplatin or anti PD-1/PD-L1 therapy in the neo- adjuvant/adjuvant setting will not be able to count that line of therapy towards eligibility for the study. * Cisplatin ineligible individuals who meet one of the below criteria and who were treated with carboplatin in the metastatic or locally advanced unresectable settings may count that line of therapy towards eligibility. They must then have received anti PD-1/PD-L1 therapy in metastatic or locally advanced unresectable setting to be eligible for the study. \-- Cisplatin ineligibility is defined as meeting one of the following criteria: * Creatinine Clearance \< 60 mL/min * Grade ≥ 2 Audiometric Hearing Loss * Grade ≥ 2 Peripheral Neuropathy * New York Heart Association (NYHA) Class III heart failure * ECOG PS ≥ 2 * Anti PD-1/PD-L1 therapy administered as part of maintenance therapy may be counted towards eligibility for the study * Individuals who have progressed after receiving enfortumab vedotin in prior lines of therapy, and individuals who are either ineligible or unable to tolerate enfortumab vedotin therapy, are eligible to enroll in the study * Individuals who received only concurrent chemoradiation for bladder preservation without further systemic therapy are not eligible to enroll in the study. The substitution of carboplatin for cisplatin does not constitute a new regimen provided no new chemotherapeutic agents were added to the regimen and no progression was noted prior to the change in platinum. * Individuals with previously treated brain metastases may participate in the study provided they have stable central nervous system disease for at least 4 weeks prior to the first dose of study drug and stabilization of all neurologic symptoms, have no evidence of new or enlarging brain metastases, and are not using steroids \>20 mg of prednisone (or equivalent) daily for brain metastases for at least 7 days prior to first dose of the study drug. * Adequate hematologic counts without transfusion or growth factor support within 2 weeks of study drug initiation (hemoglobin ≥ 9 g/dL, absolute neutrophil count (ANC) ≥1,500/mm\^3, and platelets ≥100,000/µL). * Adequate hepatic function (bilirubin ≤1.5x institutional upper limit of normal (IULN), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 2.5 x IULN or ≤ 5 x IULN if known liver metastases and serum albumin \>3 g/dL). Docetaxel will only be option in TPC arm for individuals with a total bilirubin ≤1 x IULN, and an AST and/or ALT ≤1.5x IULN if alkaline phosphatase is also \>2.5 x IULN. * Creatinine clearance ≥30 mL/min as assessed by the Cockcroft-Gault equation or other validated instruments (e.g. Modification of Diet in Renal Disease (MDRD) equation). * Females of childbearing potential must have a negative urine or serum pregnancy test within 72 hours prior to receiving the first dose of study drug. If the urine test is positive or cannot be confirmed as negative, a serum pregnancy test will be required. * Females of childbearing potential must be willing to use 2 methods of birth control or be surgically sterile or abstain from heterosexual activity for the course of the study through 6 months after the last dose of study drug. Individuals of childbearing potential are those who have not been surgically sterilized or have not been free from menses for \>2 years. * Males must agree to use an adequate method of contraception starting with the first dose of study therapy through 6 months after the last dose of study therapy. Key Exclusion Criteria: * Females who are pregnant or lactating. * Have had a prior anti-cancer monoclonal antibody (mAb)/ antibody-drug conjugate (ADC) within 4 weeks prior to Cycle 1 Day 1 (C1D1) or have had prior chemotherapy, targeted small molecule therapy, or radiation therapy within 2 weeks prior to C1D1. Individuals participating in observational studies are eligible. * Have received prior chemotherapy for UC with any available standard of care (SOC) therapies in the control arm (i.e., both prior paclitaxel and docetaxel in regions where vinflunine is not an approved therapy, or prior paclitaxel, docetaxel and vinflunine in regions where vinflunine is approved and is commercially available). * Have not recovered (i.e., ≤ Grade 1) from adverse events due to previously administered chemotherapeutic agent. * Note: Individuals with ≤ Grade 2 neuropathy or any grade of alopecia are an exception to this criterion and will qualify for the study. * Note: If Individuals received major surgery, they must have recovered adequately from the toxicity and/or complications from the intervention prior to starting study therapy. * Have previously received topoisomerase 1 inhibitors. * Have an active second malignancy. * Note: Individuals with a history of malignancy that have been completely treated and with no evidence of active cancer for 3 years prior to enrollment, or individuals with surgically cured tumors with low risk of recurrence are allowed to enroll in the study after discussion with the medical monitor. * Have active cardiac disease, defined as: * Myocardial infarction or unstable angina pectoris within 6 months of C1D1. * History of serious ventricular arrhythmia (i.e., ventricular tachycardia or ventricular fibrillation), high-grade atrioventricular block, or other cardiac arrhythmias requiring anti-arrhythmic medications (except for atrial fibrillation that is well controlled with antiarrhythmic medication); history of QT interval prolongation. * NYHA Class III or greater congestive heart failure or left ventricular ejection fraction of \<40%. * Have active chronic inflammatory bowel disease (ulcerative colitis, Crohn's disease) or gastrointestinal (GI) perforation within 6 months of enrollment. * Have an active serious infection requiring anti-infective therapy (Contact medical monitor for clarification). * Have known history of Human Immunodeficiency Virus (HIV)-1/2 with undetectable viral load and on medications that may interfere with SN-38 metabolism. * Have active Hepatitis B Virus (HBV) or Hepatitis C Virus (HCV). In individuals with a history of HBV or HCV, individuals with a detectable viral load will be excluded. * Have other concurrent medical or psychiatric conditions that, in the investigator's opinion, may be likely to confound study interpretation or prevent completion of study procedures and follow-up examinations. * Have inability to tolerate or are allergic to any potential TPC agent or sacituzumab govitecan-hziy or unable or unwilling to receive the doses specified in the protocol. * Have inability to complete all specified study procedures for any reason. Note: Other protocol defined Inclusion/Exclusion criteria may apply.
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Get notified about this study
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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1st Hospital Jilin University
Changchun, 130021, China
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401 General Military Hospital of Athens
Athens, 115 25, Greece
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Affiliated Tumor Hospital of Xinjiang Medical University
Ürümqi, 830000, China
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Alexandra General Hospital
Athens, 11528, Greece
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Anassa General Clinic
Thessaloniki, 54623, Greece
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Anhui Provincial Cancer Hospital
Hefei, 230031, China
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Asan Medical Center
Seoul, 05505, South Korea
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Ashford Cancer Centre Research - ICON Cancer Centre Adelaide
Kurralta Park, South Australia, 5037, Australia
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Asklepios Klinik Altona
Hamburg, 22763, Germany
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Athens Medical Center
Marousi, 151 25, Greece
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Attikon Hospital
Chaïdári, 124 62, Greece
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Austin Health
Heidelberg, Victoria, 3084, Australia
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Az Maria Middelares Ghent
Ghent, 9000, Belgium
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Azienda Ospedaliera Santa Maria di Terni
Terni, 05100, Italy
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Azienda Ospedaliera Universitaria Integrata Verona
Verona, 37126, Italy
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Azienda Ospedaliero Universitaria Maggiore Della Carita
Novara, 28100, Italy
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Azienda Ospedaliero Universitaria Pisana
Pisa, 56126, Italy
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Azienda Ospedaliero-Universitaria San Luigi Gonzaga
Torino, 10043, Italy
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BRCR Medical Center, Inc
San Juan, PR, 00907, Puerto Rico
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Bagcilar Medipol Mega Universite Hastanesi
Istanbul, 34214, Turkey (Türkiye)
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Baptist MD Anderson Cancer Center
Jacksonville, Florida, 32207, United States
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Barts Health NHS Trust
London, EC1A 7BE, United Kingdom
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Beijing Cancer Hospital
Beijing, 100142, China
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Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215, United States
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Bioclinic - Thessaloniki
Thessaloniki, 546 22, Greece
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Boca Raton Clinical Research Global USA - Plantation
Plantation, Florida, 33322, United States
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British Columbia Cancer Agency-Vancouver Centre
Vancouver, V5Z 4E6, Canada
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CHU Saint Andre
Bordeaux, 33075, France
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Calvary Mater Newcastle
Waratah, New South Wales, 2298, Australia
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Cancer Hospital of the University of Chinese Academy of Sciences Zhejiang Cancer Hospital
Hangzhou, 310022, China
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Cebeci Hastanesi
Mamak, 6620, Turkey (Türkiye)
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Center for Cancer and Blood Disorders
Fort Worth, Texas, 76104, United States
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Centre Antoine Lacassagne
Nice, 06189, France
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Centre Eugene Marquis
Rennes, 35042, France
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Centre Francois Baclesse
Caen, 14076, France
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Centre Georges- Francois Leclerc
Dijon, 21000, France
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Centre Hospiltalier Universitaire Brest - Hôpital Morvan
Brest, 29200, France
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Centre Hospitalier Departemental Vendee
La Roche-sur-Yon, 85925 CEDEX 9, France
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Centre Hospitalier Privé Saint-Grégoire
Saint-Grégoire, 35760, France
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Centre Hospitalier Universitaire de Liège
Liège, B-4000, Belgium
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Centre Hospitalier Universitaire de Nimes
Nîmes, 30029, France
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Centre Jean Perrin
Clermont-Ferrand, 63011, France
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Centre Leon Berard
Lyon, 69373, France
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Centre Oscar Lambret
Lille, 59000, France
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Centro Hospitalar de Leiria - Hospital de Santo André
Leiria, 2410-197, Portugal
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Centro Hospitalar de Lisboa Norte - Hospital de Santa Maria
Lisbon, 1649-035, Portugal
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Centro Hospitalar de Tras-os-Montes e Alto Douro
Vila Real, 5000, Portugal
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Centro di Riferimento Oncologico di Aviano
Aviano, 33081, Italy
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Centrum fur Hamatologie und Onkologie Bethanien
Frankfurt am Main, 60389, Germany
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Chaim Sheba Medical Center
Tel Litwinsky, 52621, Israel
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Chang Gung Memorial Hospital - Linkou Branch
Taoyuan, 333, Taiwan
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Charité Universitätsmedizin Berlin - Campus Benjamin Franklin
Wien, 1100, Germany
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Chiayi Chang Gung Memorial Hospital
Buzi, 613, Taiwan
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China Medical University Hospital
Taichung, 40447, Taiwan
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Chinese Academy of Medical Sciences Cancer Hospital
Beijing, 100730, China
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Chinese People's Liberation Army General Hospital - 301 Hospital
Beijing, 100039, China
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Chongqing University Cancer Hospital
Chongqing, 400030, China
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Chris O'Brien Lifehouse
North Ryde, New South Wales, 2109, Australia
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Chungbuk National University Hospital
Cheongju-si, 361-711, South Korea
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Chungnam National University Hospital
Daejeon, 35015, South Korea
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Cleveland Clinic
Cleveland, Ohio, 44195, United States
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Clinica Universidad de Navarra
Pamplona, 31008, Spain
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Clinical Hospital Centre "Sestre Milosrdnice"
Zagreb, 10000, Croatia
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Clinical Hospital Centre Split
Split, 21000, Croatia
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Clínica Universidad de Navarra - Madrid
Madrid, 28027, Spain
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Complexo Hospitalario de Ourense (CHOU)
Ourense, 32005, Spain
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Cross Cancer Institute
Edmonton, T6G 1Z2, Canada
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Dorset County Hospital NHS Foundation Trust
Dorchester, DT1 2JY, United Kingdom
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East and North Hertfordshire NHS Trust
Middlesex, HA6 2RN, United Kingdom
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Evex Medical corporation
Tbilisi, 0160, Georgia
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Fakultni nemocnice Olomouc
Olomouc, 775 20, Czechia
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Gachon University Gil Medical Center
Incheon, 405-760, South Korea
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Grand Hôpital De Charleroi - Notre Dame
Charleroi, 6000, Belgium
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Guys and Saint Thomas NHS Foundation Trust, Guy's Hospital
London, SE1 9RT, United Kingdom
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Hacettepe Universitesi Tip Fakultesi- Kanser Enstitusu
Ankara, 6230, Turkey (Türkiye)
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Hadassah University Hospital Ein Kerem
Jerusalem, 91120, Israel
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Harold C. Simmons Comprehensive Cancer Center
Dallas, Texas, 75390, United States
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Henry Dunant Hospital
Athens, 115 26, Greece
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High Technology Hospital MedCenter
Batumi, 6000, Georgia
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Hong Kong United Oncology Centre
Kowloon, Hong Kong
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Hospital Clinic de Barcelona
Barcelona, 8036, Spain
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Hospital General Universitario Gregorio Maranon
Madrid, 28007, Spain
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Hospital Reina Sofia
Córdoba, 14004, Spain
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Hospital Sant Joan de Déu de Manresa
Manresa, 08243, Spain
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Hospital Universitari Vall D'Hebron
Barcelona, 08035, Spain
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Hospital Universitario 12 de Octubre
Madrid, 28041, Spain
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Hospital Universitario Marqués de Valdecilla
Santander, 39008, Spain
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Hospital Universitario Puerta de Hierro de Majadahonda
Majadahonda, 28222, Spain
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Hospital Universitario Ramon y Cajal
Madrid, 28034, Spain
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Hospital Universitario Virgen del Rocio
Seville, 41013, Spain
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Hospital de Braga
Braga, 4710-243, Portugal
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Hospital del Mar - Parc de Salut
Barcelona, 08003, Spain
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Hunan Cancer Hospital - Xiangya Hospital - Central South University
Changsha, 410013, China
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Hôpital Européen Georges-Pompidou
Paris, 75015, France
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Hôpital Foch
Suresnes, 92150, France
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Hôpitaux Universitaires de Genève
Geneva, 1205, Switzerland
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ICON Cancer Centre Hobart
Hobart, Tasmania, 7001, Australia
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Icon Cancer Centre Farrer Park
Singapore, 217562, Singapore
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Icon Cancer Centre Wesley
Auchenflower, Queensland, 4066, Australia
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Institut Claudius Regaud
Toulouse, 31059, France
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Institut Für Versorgungsforschung in Der Onkologie
Koblenz, 56068, Germany
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Institut Gustave Roussy
Villejuif, 94805, France
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Institut Régional du Cancer de Montpellier ICM Val d' Aurelle
Montpellier, 34090, France
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Instituto Portugues de Oncologia do Porto Francisco Gentil, E.P.E
Porto, Portugal
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Interbalkan Medical Center of Thessaloniki
Thessaloniki, 555 35, Greece
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Istanbul Acibadem University Maslak Hospital
Istanbul, 34457, Turkey (Türkiye)
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Istituto Oncologico Della Svizzera Italiana (IOSI)
Bellinzona, 6500, Switzerland
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Istituto Regina Elena
Roma, 00144, Italy
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Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
Meldola, 47014, Italy
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Istituto Tumori Bari Giovanni Paolo II - IRCCS
Bari, 70124, Italy
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Istituto di Candiolo - Fondazione del Piemonte per l'Oncologia
Candiolo (TO), 10060, Italy
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Jerarsi Clinic
Tbilisi, 0167, Georgia
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Jewish General Hospital
Montreal, H3T 1E2, Canada
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Juravinski Hospital and Cancer Centre
Hamilton, L8V 5C2, Canada
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Kaohsiung Chang Gung Memorial Hospital
Kaohsiung City, 833, Taiwan
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Kaohsiung Veterans General Hospital
Kaohsiung City, 813, Taiwan
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Karolinska Universitetssjukhuset - Solna
Stockholm, 171 76, Sweden
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Krankenhaus Der Barmherzigen Bruder Wien
Vienna, 1020, Austria
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L. Managadze National Center of Urology
Tbilisi, 0144, Georgia
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Les Hôpitaux Universitaires de Strasbourg
Strasbourg, 67091, France
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Liaoning Cancer Hospital and Institute
Shenyang, 110042, China
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Liverpool Hospital
Nedlands, Western Australia, 6009, Australia
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London Health Sciences Centre
London, N6A 4G5, Canada
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Länssjukhuset Ryhov
Jönköping, 553 05, Sweden
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MD Anderson Cancer Center
Madrid, 28033, Spain
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Malteser Waldkrankenhaus Erlangen
Erlangen, 91054, Germany
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Mayo Clinic - Arizona
Phoenix, Arizona, 85054, United States
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McGill University Health Centre
Montreal, H4A 3J1, Canada
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MedStar Washington Hospital Center
Washington D.C., District of Columbia, 20010, United States
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Medical Park Izmır Hastanesi
Izmir, 35575, Turkey (Türkiye)
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Meir Medical Center
Kfar Saba, 44281, Israel
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Monash Health
Clayton, Victoria, 3168, Australia
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Montefiore Medical Center
The Bronx, New York, 10467, United States
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Multiprofile Hospital for Active Treatment Heart and Brain EAD
Pleven, 5800, Bulgaria
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NHS Greater Glasgow and Clyde
Glasgow, G12 0YN, United Kingdom
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Nanjing Drum Tower Hospital
Nanjing, 210008, China
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National Cancer Center
Goyang-si, 10408, South Korea
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National Cheng Kung University Hospital
Tainan, 70403, Taiwan
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National Taiwan University Hospital
Taipei, 100, Taiwan
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National University Hospital
Singapore, 119074, Singapore
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New Hospitals
Tbilisi, 0114, Georgia
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Oklahoma Cancer Specialists and Research Institute (OCSRI)
Tulsa, Oklahoma, 74104, United States
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Ordensklinikum Linz GmbH Barmherzige Schwestern
Linz, 4010, Austria
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Ospedale Civile Di Sondrio
Sondrio, 23100, Italy
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Ospedale Policlinico San Martino
Genova, 16132, Italy
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Ospedale San Donato
Arezzo, 52100, Italy
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Ospedale San Raffaele
Milan, 20132, Italy
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Ospedale di Trento - Presidio Ospedaliero Santa Chiara
Trento, 38122, Italy
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Oxford University Hospitals NHS Foundation Trust
Oxford, OX3 7LE, United Kingdom
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Peking University First Hospital
Beijing, 100034, China
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Penn State Hershey Cancer Institute
Hershey, Pennsylvania, 17033, United States
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Peter MacCallum Cancer Centre
Melbourne, Victoria, 3000, Australia
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Prince of Wales Hospital
Hong Kong, 0, Hong Kong
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Princess Margaret Cancer Centre
Toronto, M5G 2M9, Canada
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Pusan National University Hospital
Busan, 49241, South Korea
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Pusan National University Yangsan Hospital
Gyeongsangnam-do, 50612, South Korea
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Qilu Hospital of Shandong University
Jinan, 250012, China
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Queen Mary Hospital
Hong Kong, Hong Kong
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R.S. McLaughlin Durham Regional Cancer Centre
Oshawa, L1G 2B9, Canada
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Rabin Medical Center
Petah Tikva, 4941492, Israel
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Rambam Health Care Campus
Haifa, 3109601, Israel
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Ramsay Health Clinic Belharra
Bayonne, France
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Regional University General Hospital of Herakleio, Crete
Herakleio, 81352, Greece
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Roswell Park Cancer Institute
Buffalo, New York, 14263, United States
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Royal Preston Hospital
Preston, PR2 9HT, United Kingdom
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Samsung Medical Center
Seoul, 06351, South Korea
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Sarah Cannon Research Institute London
London, W1G 6AD, United Kingdom
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Seattle Cancer Care Alliance (SCCA)
Seattle, Washington, 98109, United States
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Seoul National University Bundang Hospital
Seongnam-si, 13620, South Korea
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Seoul National University Hospital
Seoul, 03080, South Korea
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Severance Hospital, Yonsei University Health System
Seoul, 03722, South Korea
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Shamir Medical Center (Assaf Harofeh)
Be’er Ya‘aqov, 7030000, Israel
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Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
Chengdu, 610072, China
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Sir Charles Gairdner Hospital
Nedlands, Western Australia, 6009, Australia
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Southern Adelaide Local Health Network Incorporated
Bedford Park, South Australia, 5042, Australia
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Specialized Hospital for Active Treatment of Oncological Diseases - Sofia District
Sofia, 1233, Bulgaria
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Studienpraxis Urologie
Nürtingen, 72622, Germany
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Summit Cancer Centers
Spokane, Washington, 99208, United States
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Sun Yat-Sen University Cancer Center
Guangzhou, 510060, China
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Sunshine Hospital
Saint Albans, Victoria, 3021, Australia
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Swansea Bay University Health Board
Port Talbot, SA12 7BR, United Kingdom
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T.C. Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi
Istanbul, 34722, Turkey (Türkiye)
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Taichung Veterans General Hospital
Taichung, Taiwan 407, Taiwan
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Taipei Tzu Chi General Hospital
New Taipei City, 231405, Taiwan
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Taipei Veterans General Hospital
Taipei, 11217, Taiwan
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Tallaght University Hospital
Dublin, D24 NR0A, Ireland
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Tan Tock Seng Hospital
Singapore, 308433, Singapore
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Tel Aviv Medical Center (Ichilov Hospital)
Tel Aviv, 6423906, Israel
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The Catholic University of Korea Saint Vincent's Hospital
Suwon, 16247, South Korea
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The Catholic University of Korea Seoul Saint Mary's Hospital
Seoul, 137-040, South Korea
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The Christie NHS Foundation Trust
Manchester, M20 4BX, United Kingdom
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The First Affiliated Hospital of Fujian Medical University
Fujian, 350005, China
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The First Affiliated Hospital of Nanchang University
Nanchang, 330006, China
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The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, 325000, China
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The Royal Marsden NHS Foundation Trust
Surrey, SM2 5PT, United Kingdom
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The Royal Wolverhampton NHS Trust
Wolverhampton, WV10 0QP, United Kingdom
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Theagenio Anticancer Hospital of Thessaloniki
Thessaloniki, 546 39, Greece
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Thompson Oncology Group - Knoxville Downtown
Knoxville, Tennessee, 37916, United States
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Tianjin Medical University Cancer Institute & Hospital
Tianjin, 300060, China
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Trakya Universitesi Saglik Arastirma ve Uygulama Merkezi
Edirne, 22030, Turkey (Türkiye)
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UCLA Hematology/ Oncology
Los Angeles, California, 90095, United States
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Unidade Local de Saúde da Guarda - Hospital Sousa Martins
Guarda, 6300-858, Portugal
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Union Hospital Tongji Medical College Huazhong University of Science and Technology
Wuhan, 430030, China
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Union Hospital of Fujian Medical University
Fuzhou, 350001, China
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Universitaetsspital Zurich - Klinik fur Medizinische Onkologie und Hematologie
Zurich, 8091, Switzerland
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Universitair Ziekenhuis Gent
Ghent, 9000, Belgium
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Universitair Ziekenhuis Leuven
Leuven, 3000, Belgium
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Universitatsklinik Dresden
Dresden, 01307, Germany
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Universitatsklinikum Munster
Münster, 48149, Germany
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Universitetssjukhuset i Linköping
Linköping, 581 85, Sweden
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University Cancer Specialists - Knoxville
Knoxville, Tennessee, 37920, United States
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University Hospital Basel
Basel, 4051, Switzerland
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University Hospital Centre Zagreb
Zagreb, Croatia
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University Hospital Of Ioannina
Ioannina, 45332, Greece
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University Hospital Waterford
Waterford, X91 ER8E, Ireland
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University Hospital of Larissa
Larissa, 413 34, Greece
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University Hospital of Patras
Pátrai, 26332, Greece
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University Hospitals Birmingham NHS Foundation Trust
Birmingham, B15 2WB, United Kingdom
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University of Bern
Bern, 3010, Switzerland
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University of California Irvine (UCIMC)
Orange, California, 92868, United States
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University of Iowa Hospitals and Clinics
Iowa City, Iowa, 52242, United States
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University of Maryland School of Medicine
Baltimore, Maryland, 21201, United States
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Università Campus Bio-Medico di Roma
Rome, 00128, Italy
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Universitätsklinik für Innere Medizin Graz
Graz, 8036, Austria
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Universitätsklinikum Essen
Essen, 45147, Germany
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Universitätsklinikum Tübingen
Tübingen, 72076, Germany
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Urocentrum Praha
Prague, 120 00, Czechia
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VKV Amerikan Hastanesi Department of Oncology
Şişli, 34365, Turkey (Türkiye)
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Weill Cornell Medical College
New York, New York, 10065, United States
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West China Hospital Sichuan University
Chengdu, 610041, China
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Westmead Hospital
Westmead, New South Wales, 2145, Australia
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Zhejiang Provincial People's Hospital - Zhaohui
Hangzhou, 310014, China
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qeii health sciences centre - VG site
Halifax, B3H 2Y9, Canada
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Álvaro Cunqueiro Hospital
Vigo, 36213, Spain