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Blood protein may flag brain risks after surgery

NCT ID NCT07509372

Knowledge-focused Sponsor: Ankara University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether a protein called S100B in the blood can help predict memory problems or confusion after surgery. Researchers followed 137 adults having elective surgery, testing their blood and thinking skills before and after the operation. The goal was to see if S100B levels or genetic differences could identify who might have trouble. This was an observational study, meaning no treatment was given—just careful measurement.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help doctors identify patients at risk for memory or confusion problems after surgery, allowing for earlier monitoring or preventive steps.
What could go wrong
This is a small, completed observational study, not a treatment trial. The findings may not apply to all surgery patients or lead to a proven test.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

137 people

The number who actually took part.

Started

Sep 2023

Finished

Nov 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consists of adult patients undergoing elective surgery under anesthesia who were prospectively enrolled. Patients were evaluated for postoperative cognitive dysfunction and postoperative delirium using standardized cognitive assessments. Perioperative blood samples were collected for the measurement of serum S100B levels and for the analysis of S100B gene polymorphisms. All participants were followed for cognitive outcomes up to 6 months after surgery.

Ages

18 to 120 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients (≥18 years) undergoing elective surgery under anesthesia * Patients able to provide informed consent * Patients with sufficient cognitive function to complete cognitive assessments * Patients who agreed to participate in follow-up evaluations Exclusion Criteria: * Patients with a history of neurological or psychiatric disorders affecting cognitive function * Patients with diagnosed dementia or severe cognitive impairment * Patients with inability to complete cognitive tests (e.g., severe visual, hearing, or language impairment) * Patients with alcohol or substance abuse * Patients undergoing emergency surgery * Patients with missing baseline cognitive assessment * Patients who refused participation or were lost to follow-up

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction delirium Emergence Delirium Neuroinflammatory Diseases Postoperative Cognitive Complications

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Delirium, postoperative Postoperative cognitive dysfunction

Contacts and locations

Locations

  • Ankara University Faculty of Medicine

    Ankara, Ankara, 06000, Turkey (Türkiye)

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